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Despite numerous breakthroughs in the field, many of the recent research advancements have not been widely integrated into clinical practice. This review highlights recent innovations in neuromuscular implants\u2014specifically those that interface with skeletal muscle\u2014which could improve the clinical translation of prosthetic technologies. Skeletal muscle provides a physiologic gateway to harness and amplify signals from the nervous system. Recent surgical advancements in muscle reinnervation surgeries leverage the \u201cbio\u2010amplification\u201d capabilities of muscle, enabling more intuitive control over a greater number of degrees of freedom in prosthetic limbs than previously achieved. We anticipate that state\u2010of\u2010the\u2010art implantable neuromuscular interfaces that integrate well with skeletal muscle and novel surgical interventions will provide a long\u2010term solution for controlling advanced prostheses. Flexible electrodes are expected to play a crucial role in reducing foreign body responses and improving the longevity of the interface. Additionally, innovations in device miniaturization and ongoing exploration of shape memory polymers could simplify surgical procedures for implanting such interfaces. Once implanted, wireless strategies for powering and transferring data from the interface can eliminate bulky external wires, reduce infection risk, and enhance day\u2010to\u2010day usability. By outlining the current limitations of neuromuscular interfaces along with potential future directions, this review aims to guide continued research efforts and future collaborations between engineers and specialists in the field of neuromuscular and musculoskeletal medicine.<\/jats:p>","DOI":"10.1002\/mus.28029","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T09:05:41Z","timestamp":1703149541000},"page":"134-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neuromuscular implants: Interfacing with skeletal muscle for improved clinical translation of prosthetic limbs"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3371-300X","authenticated-orcid":false,"given":"Kiara N.","family":"Quinn","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Johns Hopkins School of Medicine  Baltimore Maryland 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