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Evidence is emerging of training interventions to improve balance for people with CMT, but to date all have relied on clinic\u2010based treatment and equipment. This proof\u2010of\u2010concept study explored whether a multi\u2010modal program of proprioceptive rehabilitation and strength training can be delivered at home, to improve balance performance in people with CMT Type 1A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen participants with CMT Type 1A were recruited into this randomized, two\u2010arm study. Baseline assessments included measures of disease severity, posturography, physical function, and patient\u2010reported outcome measurements. All participants received one falls education session. Participants were randomized to either 12\u2009weeks of balance training or 12\u2009weeks of usual activities. The intervention comprised a home\u2010based, multi\u2010sensory balance training and proximal strengthening program, supported by three home visits from a physiotherapist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen participants completed the study. The intervention was successfully implemented and well tolerated, with high participation levels. Functional measures of balance and walking showed strong effect sizes in favor of the training group. Posturography testing demonstrated moderate improvements in postural stability favoring the intervention group. Inconsistent changes were seen in lower limb strength measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The intervention was feasible to implement and safe, with some evidence of improvement in balance performance. This supports future studies to expand this intervention to larger trials of pragmatic, home\u2010delivered programs through current community rehabilitation services and supported self\u2010management pathways.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28032","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T10:04:01Z","timestamp":1703844241000},"page":"354-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Home\u2010based multi\u2010sensory and proximal strengthening program to improve balance in<scp>Charcot\u2013Marie\u2013Tooth disease Type 1A: A<\/scp>proof of concept study"],"prefix":"10.1002","volume":"69","author":[{"given":"Magdalena M.","family":"Dudziec","sequence":"first","affiliation":[{"name":"Department of Neuromuscular Diseases University College London: Institute of Neurology London UK"},{"name":"Queen Square Centre for Neuromuscular Diseases National 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College Hospitals, NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tropman","sequence":"additional","affiliation":[{"name":"Purchasing and Stores Department The London Clinic London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariola","family":"Skorupinska","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Diseases University College London: Institute of Neurology London UK"},{"name":"Queen Square Centre for Neuromuscular Diseases National Hospital for Neurology and Neurosurgery, University College Hospitals, NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Laur\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Diseases University College London: Institute of Neurology London UK"},{"name":"Queen Square Centre for Neuromuscular Diseases National Hospital for Neurology and 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