{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:36:06Z","timestamp":1794274566315,"version":"4.9.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006396","name":"Alexion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>The CHAMPION MG study demonstrated that ravulizumab significantly improved Myasthenia Gravis\u2010Activities of Daily Living (MG\u2010ADL) and Quantitative Myasthenia Gravis (QMG) total scores versus placebo in adults with acetylcholine receptor antibody\u2010positive generalized myasthenia gravis (AChR+ gMG). This post hoc analysis aimed to assess these outcomes by time from MG diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Changes from baseline to week 26 in MG\u2010ADL and QMG total scores were analyzed by time from MG diagnosis to study entry (\u22642 vs. &gt;2\u2009years). Within each subgroup, least\u2010squares (LS) mean changes for ravulizumab and placebo were compared using mixed models for repeated measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In ravulizumab\u2010treated patients, differences in LS mean (standard error of the mean) changes from baseline to week 26 were not statistically significant in the \u22642\u2010years subgroup versus the &gt;2\u2010years subgroup for MG\u2010ADL (\u22124.3 [0.70] vs. \u22122.9 [0.37]; <jats:italic>p<\/jats:italic> = .0511) or QMG (\u22124.3 [0.94] vs. \u22122.5 [0.50]; <jats:italic>p<\/jats:italic> = .0822) scores. No clear trends were observed in the placebo group. LS mean changes from baseline were significantly greater for ravulizumab versus placebo in both the \u22642 and &gt;2\u2009years from diagnosis subgroups for MG\u2010ADL and QMG scores (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The difference in treatment effect between the \u22642\u2010years and &gt;2\u2010years subgroups was not statistically significant. No clinically meaningful between\u2010subgroup differences in treatment\u2010emergent adverse events were observed in ravulizumab\u2010treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Ravulizumab treatment improved clinical outcomes for patients with AChR+ gMG regardless of time from diagnosis. A numerical trend was observed favoring greater treatment effect with earlier versus later treatment after diagnosis. Further studies are required for confirmation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28044","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T12:24:55Z","timestamp":1708518295000},"page":"556-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of ravulizumab in patients with generalized myasthenia gravis by time from diagnosis: A post hoc subgroup analysis of the <scp>CHAMPION MG<\/scp> study"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7136-8617","authenticated-orcid":false,"suffix":"Jr","given":"James F.","family":"Howard","sequence":"first","affiliation":[{"name":"The University of North Carolina  Chapel Hill North Carolina 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School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Wiendl","sequence":"additional","affiliation":[{"name":"University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen N.","family":"Beasley","sequence":"additional","affiliation":[{"name":"Alexion, AstraZeneca Rare Disease  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Liao","sequence":"additional","affiliation":[{"name":"Alexion, AstraZeneca Rare Disease  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Meisel","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CHAMPION MG Study 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