{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T13:40:07Z","timestamp":1749044407438,"version":"3.41.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Lumbosacral radiculopathy (LR) is a common disorder. Neuromuscular ultrasound (NMU) is a rapidly evolving technique for the investigation of peripheral nerve and muscle disorders, but studies using NMU in LR are lacking. The aim of the present study was to investigate ultrasonographic neuromuscular changes distant from root compression in patients with subacute to chronic compressive LR with motor impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with unilateral subacute to chronic L4, L5, or S1 radiculopathy with motor impairment and confirmed by magnetic resonance imaging were included. The sciatic and femoral nerve cross\u2010sectional areas (CSA), the CSA of lower limb muscles, and muscle fasciculation detection rate were assessed using a pre\u2010specified neuromuscular ultrasound evaluation with blinded side\u2010to\u2010side comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 18 included patients, 66% were male and the mean age was 51\u2009years. Overall, 16.7% had L4, 55.5% L5, and 27.8% S1 radiculopathy, mostly due to disc herniation (83%). Sciatic nerve CSA of the symptomatic side was increased (61.4\u2009mm<jats:sup>2<\/jats:sup> vs. 51.3\u2009mm<jats:sup>2<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009=\u2009.001), and the fasciculation detection rate was higher in the affected muscles (delta\u2009=\u200913%, <jats:italic>p<\/jats:italic>\u2009=\u2009.007) compared to unaffected ones. Muscle CSA in affected and nonaffected muscles was decreased on the symptomatic side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>NMU evaluation in patients with symptomatic subacute to chronic LR revealed sciatic nerve enlargement distant from nerve root compression and higher fasciculation rates. These structural findings on NMU might be due to an axonal repair mechanism and an inflammatory response with endoneurial edema induced by ongoing nerve damage and potentially reflect progressive axonal loss.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28061","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T08:56:15Z","timestamp":1708678575000},"page":"566-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuromuscular ultrasound changes in unilateral symptomatic subacute lumbosacral radiculopathy: A prospective simple blinded cohort study"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2772-9574","authenticated-orcid":false,"given":"David","family":"Cuendet","sequence":"first","affiliation":[{"name":"Neurology Unit, Department of Internal Medicine Cantonal Hospital Fribourg  Fribourg Switzerland"},{"name":"Faculty of Science and Medicine University Fribourg  Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Valsecchi","sequence":"additional","affiliation":[{"name":"Faculty of Science and Medicine University Fribourg  Fribourg Switzerland"},{"name":"Neuro\u2010spinal Unit, Department of Orthopedics surgery and Traumatology Cantonal Hospital Fribourg  Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Najberg","sequence":"additional","affiliation":[{"name":"Faculty of Science and Medicine University Fribourg  Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Maestretti","sequence":"additional","affiliation":[{"name":"Faculty of Science and Medicine University Fribourg  Fribourg Switzerland"},{"name":"Neuro\u2010spinal Unit, Department of Orthopedics surgery and Traumatology Cantonal Hospital Fribourg  Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Medlin","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Internal Medicine Cantonal Hospital Fribourg  Fribourg Switzerland"},{"name":"Faculty of Science and Medicine University Fribourg  Fribourg Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318183a4a2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21166"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120803"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199502001-00001"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.4.0755"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23621"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12261"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2019.04.006"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318233b36a"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00900945"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.08.003"},{"issue":"1656","key":"e_1_2_12_13_1","first-page":"8","article-title":"Reliability and validity of panoramic ultrasound for muscle quantification","volume":"38","author":"Scott JM","year":"2012","journal-title":"Ultrasound Med Biol"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24209"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23525"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.math.2015.05.003"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msksp.2019.01.016"},{"volume-title":"Anatomical Guide for the Electromyographer: The Limbs and Trunk","year":"2011","author":"Perotto A","key":"e_1_2_12_18_1"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon19977123"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon199883148"},{"key":"e_1_2_12_21_1","unstructured":"KassambaraA.rstatix: Pipe\u2010Friendly Framework for Basic Statistical Tests. 2023.https:\/\/CRAN.R-project.org\/package=rstatix"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.03.013"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21009"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/JMU.JMU_6_17"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.15557\/JoU.2021.0018"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4704-9"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25607"}],"container-title":["Muscle &amp; 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