{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:11:13Z","timestamp":1784956273961,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017183","name":"Janssen Scientific Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017183","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>People with myasthenia gravis (MG) experience impaired quality of life. However, the impact of MG symptoms on work productivity has not been well\u2010studied. We aimed to evaluate this impact and to examine associations between disease severity and the degree of impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were drawn from the Adelphi MG Disease\u2010Specific Programme\u2122, a multinational (USA, France, Germany, Italy, Spain, UK) survey completed by physicians and their patients with MG in 2020. Patient\u2010reported measures included the Work Productivity and Activity Impairment (WPAI): Specific Health Problem questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The WPAI questionnaire was completed by 330 patients. Among those currently employed, the mean percentage of work time missed (absenteeism) was 13.3% (<jats:italic>N<\/jats:italic>\u2009=\u2009116), percentage impairment of productivity at work (presenteeism) was 26.7% (<jats:italic>N<\/jats:italic>\u2009=\u2009121), and overall work impairment was 30.0% (<jats:italic>N<\/jats:italic>\u2009=\u2009110). Across all patients, impairment of non\u2010work\u2010related activities due to health problems (ADL impairment) was 39.2% (<jats:italic>N<\/jats:italic>\u2009=\u2009330). Regression analysis indicated that impairment differed according to MG Foundation of America (MGFA) class (<jats:italic>p<\/jats:italic>\u2009=\u2009.0147, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001 and <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001 for absenteeism, presenteeism, overall work impairment and ADL impairment, respectively). Being MGFA class III\/IV was a predictor of presenteeism, overall work impairment and ADL impairment in a predictor model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Patients with MG experience substantial work impairment particularly those with more severe symptoms, highlighting an important way in which patient quality of life is negatively affected. More effective treatment strategies would enable patients to lead more productive lives and could impact decisions relating to work and career.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28063","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T09:17:56Z","timestamp":1707815876000},"page":"428-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The impact of myasthenia gravis severity on work and daily activities"],"prefix":"10.1002","volume":"69","author":[{"given":"Jacqueline","family":"Pesa","sequence":"first","affiliation":[{"name":"Janssen Scientific Affairs, LLC  Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zia","family":"Choudhry","sequence":"additional","affiliation":[{"name":"Janssen Scientific Affairs, LLC  Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2100-5279","authenticated-orcid":false,"given":"Jonathan","family":"de Courcy","sequence":"additional","affiliation":[{"name":"Adelphi Real World  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Barlow","sequence":"additional","affiliation":[{"name":"Adelphi Real World  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Chatterton","sequence":"additional","affiliation":[{"name":"Adelphi Real World  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Thomas","sequence":"additional","affiliation":[{"name":"Adelphi Real World  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Gibson","sequence":"additional","affiliation":[{"name":"Adelphi Real World  Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethan","family":"Hahn","sequence":"additional","affiliation":[{"name":"Bethan Hahn Communications, LTD.  Macclesfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghav","family":"Govindarajan","sequence":"additional","affiliation":[{"name":"HSHS Medical Group Multispecialty Care \u2010 St. Elizabeth's  O'Fallon Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120268"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010021\u201010891\u20101"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2012.06817.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.553626"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506310"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802457040"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102015\u2010010352"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S120101"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053\u2010199304050\u201000006"},{"key":"e_1_2_12_11_1","unstructured":"EphMRA EphMRA.Code of conduct 2021.2021Accessed July 7 2022.https:\/\/www.ephmra.org\/sites\/default\/files\/2022-03\/2021%2520EPHMRA%2520Code%2520of%2520Conduct%25202.11.21.pdf"},{"key":"e_1_2_12_12_1","unstructured":"US Department of Health & Human Services.Summary of the HIPAA privacy rule.2020Accessed July 7 2022.http:\/\/www.hhs.gov\/sites\/default\/files\/privacysummary.pdf"},{"key":"e_1_2_12_13_1","unstructured":"US Department of Health & Human Services.Technology HI Health Information Technology Act.2009Accessed July 7 2022.https:\/\/www.hhs.gov\/sites\/default\/files\/ocr\/privacy\/hipaa\/administrative\/enforcementrule\/enfifr.pdf?language=es"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010012\u20101170\u20102"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20108\u2010129"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.01.002"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010022\u201000408\u2010x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27443"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1044\/2021_PERSP\u201021\u201000162"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010015\u20107853\u2010x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010019\u20101495\u2010z"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket300"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010publhealth\u2010031816\u2010044628"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102016\u2010013278"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0000000000000391"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.46497\/ArchRheumatol.2020.7405"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317701843"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033211045063"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033211052485"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010020\u201004838\u2010z"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2021.1981468"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2020.26.11.1424"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756\u2010185X.14120"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14056"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102377\u201014\u2010142"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2021.0146"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14050"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2023.2172282"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000002001"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000001291"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2021.1945242"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010009\u20105256\u20106"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2016.11.003"}],"container-title":["Muscle &amp; 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