{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:22:25Z","timestamp":1785424945096,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Enteral feeding via gastrostomy is a key intervention to prevent significant weight loss in Motor Neuron Disease (MND). The aim of this study was to explore demographic, clinical, and nutritional factors associated with survival time in MND patients with gastrostomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The retrospective study analyzed 94 MND patients (<jats:italic>n<\/jats:italic>\u2009=\u200958 bulbar\u2010onset and <jats:italic>n<\/jats:italic>\u2009=\u200936 limb\u2010onset) who underwent gastrostomy between 2015 and 2021. The primary outcome was the survival time from gastrostomy insertion to death. Independent variables of interest explored were: age at gastrostomy insertion, disease onset type, known genetic cause, use of riluzole, non\u2010invasive ventilation (NIV) use, forced vital capacity prior to gastrostomy, weight loss from diagnosis to gastrostomy insertion, and body mass index (BMI) at the time of gastrostomy insertion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median survival time from gastrostomy to death was 357\u2009days (\u00b1\u200929.3, 95%CI: 299.5, 414.5). Kaplan\u2013Meier method and log\u2010rank test revealed patients with lower body mass index &lt;18.5\u2009kg\/m<jats:sup>2<\/jats:sup> at the time of gastrostomy insertion (<jats:italic>p<\/jats:italic>\u2009=\u2009.023) had shorter survival. Cox proportional hazards model with multivariable adjustment revealed that older age (<jats:italic>p<\/jats:italic>\u2009=\u2009.008), and greater weight loss from diagnosis to gastrostomy (<jats:italic>p<\/jats:italic>\u2009=\u2009.003) were associated with shorter survival time post gastrostomy. Limb onset (<jats:italic>p<\/jats:italic>\u2009=\u2009.023), NIV use not being required (<jats:italic>p<\/jats:italic>\u2009=\u2009.008) and daily NIV use when required and tolerated (<jats:italic>p<\/jats:italic>\u2009=\u2009.033) were associated with longer survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Preventing or minimizing weight loss from MND diagnosis and encouraging NIV use when clinically indicated are modifiable factors that may prolong the survival of MND patients with gastrostomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28064","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T11:59:01Z","timestamp":1707911941000},"page":"440-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical prognostic factors predicting survival of motor neuron disease patients with gastrostomy: A retrospective analysis"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-4244","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"Curtin School of Population Health, Faculty of Health Science Curtin University  Perth Western Australia Australia"},{"name":"Department of Nutrition and Dietetics Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Curtin School of Population Health, Faculty of Health Science Curtin University  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Soares","sequence":"additional","affiliation":[{"name":"Curtin School of Population Health, Faculty of Health Science Curtin University  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merrilee","family":"Needham","sequence":"additional","affiliation":[{"name":"Department of Neurology Fiona Stanley Hospital  Perth Western Australia Australia"},{"name":"Faculty of Medicine University of Notre Dame, Perth, Western Australia, Australia CMMIT Murdoch University  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Begley","sequence":"additional","affiliation":[{"name":"Curtin School of Population Health, Faculty of Health Science Curtin University  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Calton","sequence":"additional","affiliation":[{"name":"Curtin School of Population Health, Faculty of Health Science Curtin University  Perth Western Australia Australia"},{"name":"School of Allied Health, Faculty of Health Sciences Curtin University  Perth Western Australia Australia"},{"name":"South Metropolitan Health Service Harry Perkins Institute  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.05.014"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2019.1587631"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820410020349"},{"key":"e_1_2_13_5_1","volume-title":"Health and Care Excellence (UK) Copyright \u00a9 National Clinical Guideline Centre","author":"National Clinical Guideline 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