{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:25:14Z","timestamp":1788827114767,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Glucocorticoids (GC) are first\u2010line therapy for many neuromuscular diseases. There is a lack of guidelines regarding the prevention and management of GC complications in the context of neuromuscular disease, introducing the potential for practice variation, that may compromise quality of care. Our aim was to evaluate the practice patterns among Canadian adult neuromuscular neurologists on the screening, management, and treatment of GC\u2010related complications and to identify variances in practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A web\u2010based anonymous questionnaire was disseminated to 99 Canadian adult neuromuscular neurologists. Questions addressed patterns of screening, prevention, monitoring, and treatment of GC\u2010induced adverse events, including infection prophylaxis, vaccination, bone health, hyperglycemia, and other complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010one percent completed the survey. Of those, 52% perform screening blood work prior to initiating GC, 56% screen for infections, and 18% for osteoporosis. The majority monitor glycemic control and blood pressure (&gt;85%). Thirty\u2010two (46%) reported that they do not primarily monitor GC complications, but rather provide recommendations to the primary care physician. <jats:italic>Pneumocystis jiroveci<\/jats:italic> pneumonia prophylaxis was never used by 29%, and 29% recommend vaccinations prior to GC initiation. Calcium supplementation was recommended by 80% to prevent osteoporosis. Only 36% were aware of any existing guidelines for preventing GC complications, and 91% endorsed a need for neurology\u2010specific guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>There is substantial variability in the management of GC adverse effects among neuromuscular neurologists, often not corresponding to limited published literature. Our results support the need for improved education and neurology\u2010specific guidelines to help standardize practice and improve and prevent complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28069","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T10:11:40Z","timestamp":1709028700000},"page":"52-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic glucocorticoid management in neuromuscular disease: A survey of neuromuscular neurologists"],"prefix":"10.1002","volume":"70","author":[{"given":"Lora","family":"Stepanian","sequence":"first","affiliation":[{"name":"School of Medicine Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruple S.","family":"Laughlin","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Bacher","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine Scarborough Health Network and University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Izenberg","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine Sunnybrook Health Sciences Centre and University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Hodgkinson","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienna","family":"Dyck","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute, University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5225-3208","authenticated-orcid":false,"given":"Ari","family":"Breiner","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-8787","authenticated-orcid":false,"given":"Charles D.","family":"Kassardjian","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine Unity Health Toronto and University of Toronto  Toronto Ontario Canada"},{"name":"Li Ka Shing Knowledge Institute, Unity Health Toronto  Toronto Ontario Canada"},{"name":"Neurology Quality and Innovation Lab  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26382"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003725.pub4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND\u2010200612"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14153"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.08.004"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010018\u20101588\u20102"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3239036478"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13675"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23279"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2018.03.009"},{"key":"e_1_2_12_12_1","unstructured":"Vaccine Recommendations and Guidelines of the ACIP [Internet]. 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