{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:01:09Z","timestamp":1784203269505,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005642","name":"Universit\u00e0 degli Studi di Sassari","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>The global incidence and prevalence of myasthenia gravis (MG) range between 6\u201331\/million and 10\u201337\/100,000, respectively. Sardinia is a high\u2010risk region for different immune\u2010mediated disorders, but the epidemiology of MG remains unclear. We determined the epidemiology of MG with acetylcholine receptor (AChR)\u2010immunoglobulin G (IgG) and muscle\u2010specific tyrosine kinase (MuSK)\u2010IgG in the district of Sassari (North\u2010Western Sardinia; population, 325,288).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the laboratory of the University Hospital of Sassari (reference for AChR\/MuSK\u2010IgG testing in Sardinia since 1998) and the main neurology units in Sardinia, we retrospectively identified MG patients with (1) AChR\u2010IgG and\/or MuSK\u2010IgG positivity by radioimmunoprecipitation assay; and (2) residency in the district of Sassari. Incidence (January 2010\u2013December 2019) and prevalence (December 31, 2019) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 202 patients were included (incident, 107; prevalent, 180). Antibody specificities were AChR (<jats:italic>n<\/jats:italic>\u2009=\u2009187 [93%]) and MuSK (<jats:italic>n<\/jats:italic>\u2009=\u200915 [7%]). The crude MG incidence (95% confidence interval) was 32.6 (26.8\u201339.2)\/million, while prevalence was 55.3 (47.7\u201363.9)\/100,000. After age\u2010standardization to the world population, incidence decreased to 18.4 (14.3\u201322.5)\/million, while prevalence decreased to 31.6 (26.1\u201337.0)\/100,000. Among incident cases, age strata (years) at MG onset were: &lt;18 (2%), 18\u201349 (14%), 50\u201364 (21%), and \u226565 (63%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Sardinia is a high\u2010risk region for MG, with a prevalence that exceeds the European threshold for rare disease. Identification of the environmental and genetic determinants of this risk may improve our understanding of disease pathophysiology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28077","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T09:19:00Z","timestamp":1709889540000},"page":"637-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Epidemiology of seropositive myasthenia gravis in <scp>Sardinia<\/scp>: A population\u2010based study in the district of <scp>Sassari<\/scp>"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-663X","authenticated-orcid":false,"given":"Elia","family":"Sechi","sequence":"first","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni A.","family":"Deiana","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Puci","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Pharmacy University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Zara","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences University of Sassari  Sassari Italy"},{"name":"Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Ortu","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Porcu","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera G. Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Carboni","sequence":"additional","affiliation":[{"name":"Neurology Unit Ospedale San Francesco  Nuoro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Chessa","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences University of Sassari  Sassari Italy"},{"name":"Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Ruiu","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Nieddu","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Tacconi","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Russo","sequence":"additional","affiliation":[{"name":"Neurology Service, ASL Sassari  Alghero Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Manca","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera G. Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Margherita","family":"Sechi","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Guida","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3260-1754","authenticated-orcid":false,"given":"Tommaso","family":"Ercoli","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello M.","family":"Mascia","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Muroni","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Profice","sequence":"additional","affiliation":[{"name":"Neurology Unit Mater Olbia Hospital  Olbia Italy"},{"name":"Neurology Unit Fondazione Policlinico Gemelli  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Saddi","sequence":"additional","affiliation":[{"name":"Neurology Unit Ospedale San Francesco  Nuoro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Melis","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera G. 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