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Early and accurate recognition, treatment, and management of workplace factors rely on a thorough understanding of the anatomic and biomechanical factors that drive nerve injury. This review explores the interplay between anatomy, biomechanics, and nerve pathology common to occupational nerve injury and provides the treating physician with a rational, evidence\u2010based approach to diagnosis and to occupational aspects of management. Assessment of potential occupational nerve injury begins with a detailed understanding of the employee's work duties through a biomechanical lens. One must consider likelihood of occupational causation while accounting for predisposing conditions or preexisting symptoms. Beyond overt crush injury or laceration, potential mechanisms of nerve injury, with effects compounded over time, include compression, stretch, vibration, and repetitive or high\u2010force movements of regional muscles and joints. Injury often occurs at nerve locations that experience higher pressures, changes in pressure over time, or abrupt changes in trajectory, often near a tethered point. This understanding, coupled with condition\u2010specific knowledge presented in this review, equips managing physicians to diagnose occupational nerve injury and enhance treatment recommendations with rational activity modifications or equipment that can protect the nerve or decrease likelihood of continued injury. Long\u2010term management often involves follow\u2010up to assess effectiveness of interventions in the setting of the work environment, with gradual progression of the worker toward return to unrestricted duty or to a point of maximal medical improvement.<\/jats:p>","DOI":"10.1002\/mus.28099","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T13:24:47Z","timestamp":1715174687000},"page":"732-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Occupational nerve injuries"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9748-697X","authenticated-orcid":false,"given":"Sandra L.","family":"Hearn","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn P.","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Albany Medical College  Albany New York USA"},{"name":"Department of Family Medicine Larner Medical College at the University of Vermont  Burlington Vermont USA"},{"name":"Adirondack Rehabilitation Medicine, PLLC  Queensbury New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8637-4509","authenticated-orcid":false,"given":"Joelle M.","family":"Gabet","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation MetroHealth Rehabilitation Institute, Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7617-4750","authenticated-orcid":false,"given":"Gregory T.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Providence St Lukes Rehabilitation Medical Center, St Luke's Rehabilitation Institute, Elson S. 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