{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:36:31Z","timestamp":1789907791368,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>There is a lack of studies comparing the accuracy of neuromuscular jitter analysis during voluntary activation (v\u2010jitter study) versus axonal stimulation (s\u2010jitter study). The study aimed to compare these two techniques in the same population of patients with suspected ocular myasthenia gravis (OMG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen control subjects (mean age: 55.5\u2009\u00b1\u200915.2\u2009years) and 34 patients with suspected OMG (mean age: 59\u2009\u00b1\u200913.9\u2009years) were prospectively evaluated. Twenty spike pairs and 30 individual spikes were analyzed during v\u2010jitter and s\u2010jitter study, respectively. Two different criteria for abnormal individual jitter values were evaluated: \u2265 or &gt; than 10% values exceeding the upper normal limit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>OMG was diagnosed in 19 patients based on clinical and laboratory findings, without considering jitter measurements. In most patients, v\u2010jitter and s\u2010jitter analyses provided comparable results. The maximum sensitivity (89%) was achieved with s\u2010jitter study using the \u226510% criterion, while the maximum specificity (93%) was found with v\u2010jitter study using the &gt;10% criterion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Both v\u2010jitter and s\u2010jitter studies showed good to very good accuracy for the diagnosis of OMG, in the absence of any statistically significant difference. Therefore, the patient's cooperation level and examiner's experience should guide the choice of performing v\u2010jitter or s\u2010jitter analysis in patients with suspected OMG.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28202","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T07:15:09Z","timestamp":1720854909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic accuracy of voluntary and stimulated neuromuscular jitter studies in ocular myasthenia gravis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-6410","authenticated-orcid":false,"given":"Giuseppe","family":"Cosentino","sequence":"first","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"Translational Neurophysiology Research Unit IRCCS Mondino Foundation  Pavia 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