{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:22:41Z","timestamp":1772994161734,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>\n                      In Guillain\u2013Barr\u00e9 syndrome (GBS), patients with dysautonomia demonstrate sympathetic overactivity (SO). This study assessed the role of prazosin (\u03b1\n                      <jats:sub>1<\/jats:sub>\n                      \u2010blocker) in the management of SO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort study was conducted from January 2022 to September 2023. Thirty\u2010two GBS patients with SO received prazosin (2.5\u201310\u2009mg three times a day) (prazosin group). For comparison, we included historical controls that included 33 GBS patients having SO with similar baseline characteristics, including median age and disability, who did not receive prazosin, from a GBS registry of patients admitted during February 2018\u2013December 2021. The primary endpoint was days to resolution of SO. Secondary endpoints were daily fluctuations in the systolic (SBP) and diastolic blood pressure (DBP), duration of hospital stay, in\u2010hospital mortality, and disability at 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median ages of both the treatment and the control groups were 36 (IQR 25\u201349) years and 43 (66.2%) were males. The demographic and clinical parameters were comparable. Prazosin resulted in significantly earlier normalization of SO compared to the control group (median 15 vs. 20\u2009days;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01). The mean fluctuations in the SBP and DBP at 15\u2009days were significantly lower in the prazosin group. However, the duration of hospital stay and good recovery at 3\u2009months were comparable. Three patients developed hypotension, while two patients died (ventilator\u2010associated pneumonia) in the prazosin group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study provides new evidence supporting the role of prazosin in SO, and needs randomized trials to confirm our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.28236","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T01:53:12Z","timestamp":1724377992000},"page":"963-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of prazosin in patients with Guillain\u2013Barr\u00e9 syndrome with sympathetic overactivity: A cohort study"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4113-9186","authenticated-orcid":false,"given":"Mritunjai","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  Rishikesh Uttrakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Guin","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  Rishikesh Uttrakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  Rishikesh Uttrakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajni","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology All India Institute of Medical Sciences  Rishikesh Uttrakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashutosh","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  Rishikesh Uttrakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","first-page":"II96","article-title":"Autonomic dysfunction in Guillain\u2013Barr\u00e9 syndrome and multiple sclerosis","volume":"254","author":"Flachenecker P","year":"2007","journal-title":"J Neurol"},{"issue":"9497","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0140-6736(05)67665-9","article-title":"Guillain\u2013Barr\u00e9 syndrome","volume":"366","author":"Hughes 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