{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:49:52Z","timestamp":1784616592434,"version":"3.55.0"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","award":["13\/LO\/1748"],"award-info":[{"award-number":["13\/LO\/1748"]}],"id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Available studies on scoliosis surgery in spinal muscular atrophy (SMA) have focused on the primary outcome of the procedure\u2014the correction of the curve\u2014whereas research focusing on secondary outcomes is scarce. We aimed to investigate postsurgical changes in respiratory function, motor function, weight, pain, and satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the clinical notes of 32 disease\u2010modifying treatment\u2010na\u00efve patients (26 SMA2, 6 nonambulant SMA3). We also performed investigator\u2010developed phone interviews and conducted a focus group with families on postsurgical satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean annual rate of forced vital capacity percent decline improved in SMA2: \u22123.2% postsurgery versus \u22126.9% presurgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), with similar trajectories in SMA3. Gross motor functional scores (Hammersmith Functional Motor Scale) available in 12\/32 dropped immediately after surgery: median loss of 6.5 points, with relatively spared upper limb function. Weight\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores postsurgery dropped in 16\/32, requiring food supplements (5\/16); one\/16 lost &gt;5% of total weight requiring gastrostomy. Postsurgical pain was frequently reported, especially hip pain (13\/32). Overall, 10\/10 patients\/parents participating in the phone interview rated the procedure as very successful for posture and physical appearance. Nonetheless, 7\/10 reported postsurgical pain, reduced mobility, and unmet care needs. The seven patients\/parents attending the focus group highlighted lack of intensive physiotherapy programs, occupational therapy assistance, and psychological support as postsurgical unmet care needs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study reports a positive impact of scoliosis surgery on respiratory function and overall satisfaction with posture and physical appearance. The observed negative impact on the other outcomes highlights the importance of multidisciplinary approaches to improve postoperative management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.28238","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:58:44Z","timestamp":1725497924000},"page":"1000-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Secondary outcomes of scoliosis surgery in disease\u2010modifying treatment\u2010na\u00efve patients with spinal muscular atrophy type 2 and nonambulant type 3"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-2848","authenticated-orcid":false,"given":"Chiara","family":"Brusa","sequence":"first","affiliation":[{"name":"Dubowitz Neuromuscular Centre, NIHR Great Ormond Street Hospital Biomedical Research Centre, Great Ormond Street Institute of Child Health University College 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Great Ormond Street Hospital Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan Y","family":"Manzur","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinki","family":"Munot","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sarkozy","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre, NIHR Great Ormond Street Hospital Biomedical Research Centre, Great Ormond Street Institute of Child Health University College London, &amp; Great Ormond Street Hospital Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Main","sequence":"additional","affiliation":[{"name":"Dubowitz 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