{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:22:28Z","timestamp":1772994148862,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001797","name":"Curtin University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Motor neuron disease (MND) is a progressive neurodegenerative condition with a limited life expectancy. There is very little data on mortality and its associated factors beyond 30\u2009days following gastrostomy. We explored the demographic, clinical, and nutritional predictors for early mortality at 30, 90, and 180\u2009days following gastrostomy in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study involving 94 MND patients in Western Australia who underwent gastrostomy between 2015 and 2021. Patients were divided into two groups based on mortality at 30, 90, and 180\u2009days post\u2010gastrostomy. T\u2010test (or Mann\u2013Whitney), chi\u2010square test and Fisher's exact test were used for detecting between\u2010group differences in various factors. Multivariable logistic regression was used to identify factors associated with post\u2010gastrostomy mortality at 90 and 180\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No mortality was attributable to gastrostomy\u2010related complications. Lower forced vital capacity (FVC) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.039) and greater weight loss (%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.022) from diagnosis to gastrostomy were observed in those who died within 30\u2009days post\u2010gastrostomy. Older age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.022), male sex (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.041), lower FVC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.04), requiring but not tolerating noninvasive ventilation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.035), and greater weight loss (%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.012) were independent predictors of 90\u2010day post\u2010gastrostomy mortality. However, only older age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01) and greater weight loss (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.009) were predictors of mortality at 180\u2009days post\u2010gastrostomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our data indicated that mortality at 90 and 180\u2009days was influenced by the weight loss (%) from diagnosis to gastrostomy, highlighting the importance of nutritional care in the MND population. Gastrostomy placement prior to substantial weight loss may reduce the risk of weight loss\u2010associated mortality and warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.28245","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T06:56:59Z","timestamp":1725605819000},"page":"1010-1017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of mortality post\u2010gastrostomy in motor neuron disease patients"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-4244","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"Curtin School of Population Health, Faculty of Health Science Curtin University  Perth Western Australia Australia"},{"name":"Department of Nutrition and Dietetics Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Curtin School of Population Health, Faculty of Health Science Curtin University  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Soares","sequence":"additional","affiliation":[{"name":"Curtin School of Population Health, Faculty of Health Science Curtin University  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merrilee","family":"Needham","sequence":"additional","affiliation":[{"name":"Department of Neurology Fiona Stanley Hospital  Perth Western Australia Australia"},{"name":"Faculty of Medicine University of Notre Dame  Perth Western Australia Australia"},{"name":"Centre for Molecular Medicine and Innovative Therapeutics (CMMIT) Murdoch University  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Begley","sequence":"additional","affiliation":[{"name":"Curtin School of Population Health, Faculty of Health Science Curtin University  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Calton","sequence":"additional","affiliation":[{"name":"Curtin School of Population Health, Faculty of Health Science Curtin University  Perth Western Australia Australia"},{"name":"School of Allied Health, Faculty of Health Sciences Curtin University  Perth Western Australia Australia"},{"name":"South Metropolitan Health Service Harry Perkins Institute  Murdoch Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.09.003"},{"key":"e_1_2_13_3_1","unstructured":"National Clinical Guideline C.National Institute for Health and Care Excellence: clinical guidelines. Motor neurone disease: assessment and management. 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