{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:22:33Z","timestamp":1772994153162,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","award":["IT\u2010SPN\u201011535"],"award-info":[{"award-number":["IT\u2010SPN\u201011535"]}],"id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Nusinersen intrathecal administration can be challenging in spinal muscular atrophy (SMA) adults. We aimed to determine if the ultrasound (US)\u2010assistance reduces the number of needle attempts and needle redirections needed for intrathecal drug administration and its impact on the procedure time, the incidence of adverse events (AEs), and patient satisfaction in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010eight patients aged 18\u2009years and older scheduled for intrathecal nusinersen injection were enrolled and randomized (1:1 ratio) into Group 1 (nusinersen infusion with US\u2010assisted technique) or Group 2 (nusinersen infusion with landmark\u2010based technique). The number of attempts, number of redirections, periprocedural time, AEs and patient satisfaction were reported. Continuous variables were compared with the Student\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test or Wilcoxon rank sum test. Categorical variables were evaluated with the Chi\u2010square test or Fisher's exact test in case of expected frequencies &lt;5. The\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values &lt;.05 were considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no statistical differences in the number of attempts, AEs, or patient satisfaction between the two groups. The number of needle redirections was significantly lower in the ultrasound group versus landmark\u2010based group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05) in both the overall group of patients and in the subgroup with difficult spines. The periprocedural time was about 40\u2009seconds longer in US\u2010group versus landmark\u2010based group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In SMA adults, US assistance reduces the number of needle redirections needed for intrathecal drug administration. These results suggest that the US assistance may be advantageous for nusinersen therapy to reduce the therapeutic burden of intrathecal infusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.28248","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T02:54:06Z","timestamp":1725850446000},"page":"1018-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound assisted versus landmark based intrathecal administration of nusinersen in adults with spinal muscular atrophy disease:\n                    <scp>A<\/scp>\n                    randomized trial"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-5382","authenticated-orcid":false,"given":"Bruno Antonio","family":"Zanfini","sequence":"first","affiliation":[{"name":"Department of Emergency, Anesthesiological and Reanimation Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Catarci","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anesthesiological and Reanimation Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata Katia","family":"Patanella","sequence":"additional","affiliation":[{"name":"Centro Clinico Nemo Adulti Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Vassalli","sequence":"additional","affiliation":[{"name":"Obstetric Anesthesia, Department of Critical Care and Perinatal Medicine Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Giannina Gaslini  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Frassanito","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anesthesiological and Reanimation Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marika","family":"Pane","sequence":"additional","affiliation":[{"name":"Centro Clinico Nemo Pediatrico Fondazione Policlinico Universitario A Gemelli IRCCS  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Biancone","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anesthesiological and Reanimation Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Di Muro","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anesthesiological and Reanimation Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1989-5839","authenticated-orcid":false,"given":"Eleonora","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anesthesiological and Reanimation Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio Maria","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Centro Clinico Nemo Pediatrico Fondazione Policlinico Universitario A Gemelli IRCCS  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Sabatelli","sequence":"additional","affiliation":[{"name":"Centro Clinico Nemo Adulti Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Draisci","sequence":"additional","affiliation":[{"name":"Department of Emergency, Anesthesiological and Reanimation Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"U.S. Food & Drug Administration.Commissioner of the FDA approves first drug for spinal muscular atrophy.2019.http:\/\/www.fda.gov\/news\u2010events\/press\u2010announcements\/fda\u2010approves\u2010first\u2010drug\u2010spinal\u2010muscular\u2010atrophy"},{"key":"e_1_2_11_3_1","unstructured":"European Medicines Agency.Summary of the European public assessment report (EPAR) Spinraza. 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