{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:19:11Z","timestamp":1791854351736,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:00:00Z","timestamp":1725667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:00:00Z","timestamp":1725667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["NIH NHLBI K23 HL\u2010151879"],"award-info":[{"award-number":["NIH NHLBI K23 HL\u2010151879"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Noninvasive ventilation (NIV) has been shown to improve survival and symptom burden in patients with amyotrophic lateral sclerosis (ALS). However, limited data exist regarding the clinical and physiological parameters at the time of NIV initiation. This study aimed to describe the clinical characteristics and respiratory physiological markers in a cohort of ALS patients with chronic respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a single\u2010center retrospective cohort study of patients with ALS assessed for NIV initiation between February 2012 and January 2021. NIV was initiated based on insurance eligibility criteria: daytime hypercapnia, defined by partial pressure of carbon dioxide (PaCO\n                      <jats:sub>2<\/jats:sub>\n                      ) &gt;45\u2009mm Hg using diurnal transcutaneous CO\n                      <jats:sub>2<\/jats:sub>\n                      (TcCO\n                      <jats:sub>2<\/jats:sub>\n                      ) as a surrogate, a maximal inspiratory pressure (MIP) &lt;60\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O or forced vital capacity (FVC) &lt;50% predicted normal.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 335 patients with ALS and chronic respiratory failure referred to an outpatient home ventilation clinic for NIV initiation. The mean age was 64\u2009years \u00b111; 151 (45%) were female, 326 (97%) were white, and 100 (29%) had bulbar\u2010onset ALS. At the time of NIV initiation, the mean FVC was 64%\u2009\u00b1\u200919%, the mean MIP; 41 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O\u2009\u00b1\u200917, and diurnal TcCO\n                      <jats:sub>2<\/jats:sub>\n                      ; 40\u2009\u00b1\u20096\u2009mmHg. The most common reasons for NIV initiation were MIP &lt;60 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O (58%) and multiple concomitant indications (28%). Within 1\u2009year of NIV initiation, 126 (37%) patients were deceased.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We found that impairment in inspiratory force was the most common reason for NIV initiation and often preceded significant declines in FVC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.28250","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T04:30:29Z","timestamp":1725683429000},"page":"1099-1103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Initiation of noninvasive ventilation in patients with amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-0327","authenticated-orcid":false,"given":"Jose Victor","family":"Jimenez","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Tang","sequence":"additional","affiliation":[{"name":"University of Michigan School of Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew W.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-5352","authenticated-orcid":false,"given":"Alexander H.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4379-1255","authenticated-orcid":false,"given":"Jason","family":"Ackrivo","sequence":"additional","affiliation":[{"name":"Pulmonary, Allergy, and Critical Care Division, Department of Medicine Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Division of Pulmonary, and Critical Care and Sleep Medicine, Department of Medicine NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.06.035"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70326-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003158"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-221658"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202002-169OC"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13547"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960701262392"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27779"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03501.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.03.011"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.05.075"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bc0141"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960601030188"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200758"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2016.1236817"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12523-w"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00438-2022"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02236"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100009653"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00388-2022"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202005-1687OC"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.10813"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2016.12.3.361"}],"container-title":["Muscle &amp; 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