{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:44:39Z","timestamp":1789343079388,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Fat\u2010referenced magnetic resonance imaging (MRI) has emerged as a promising volumetric technique for measuring muscular volume and fat in neuromuscular disorders, but the experience in inflammatory myopathies remains limited. Therefore, this work aimed at describing how sporadic inclusion body myositis (sIBM) manifests on standardized volumetric fat\u2010referenced MRI muscle measurements, including within\u2010scanner repeatability, natural progression rate, and relationship to clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten sIBM patients underwent whole\u2010leg Dixon MRI at baseline (test\u2013retest) and after 12\u2009months. The lean muscle volume (LMV), muscle fat fraction (MFF), and muscle fat infiltration (MFI) of the quadriceps, hamstrings, adductors, medial gastrocnemius, and tibialis anterior were computed. Clinical assessments of IBM Functional Rating Scale (IBMFRS) and knee extension strength were also performed. The baseline test\u2013retest MRI measurements were used to estimate the within\u2010subject standard deviation (s<jats:sub>w<\/jats:sub>). 12\u2010month changes were derived for all parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MRI measurements showed high repeatability in all muscles; s<jats:sub>w<\/jats:sub> ranged from 2.7 to 18.0\u2009mL for LMV, 0.7\u20131.3 percentage points (pp) for MFF, and 0.2\u20130.7\u2009pp for MFI. Over 12\u2009months, average LMV decreased by 7.4% while MFF and MFI increased by 3.8\u2009pp and 1.8\u2009pp, respectively. Mean IBMFRS decreased by 2.4 and mean knee extension strength decreased by 32.8\u2009N.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The MRI measurements showed high repeatability and 12\u2010month changes consistent with muscle atrophy and fat replacement as well as a decrease in both muscle strength and IBMFRS. Our findings suggest that fat\u2010referenced MRI measurements are suitable for assessing disease progression and treatment response in inflammatory myopathies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28252","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T05:33:53Z","timestamp":1727242433000},"page":"1181-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Volumetric muscle composition analysis in sporadic inclusion body myositis using fat\u2010referenced magnetic resonance imaging: <scp>Disease<\/scp> pattern, repeatability, and natural progression"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6837-4733","authenticated-orcid":false,"given":"John","family":"Heerfordt","sequence":"first","affiliation":[{"name":"AMRA Medical AB  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-8274","authenticated-orcid":false,"given":"Markus","family":"Karlsson","sequence":"additional","affiliation":[{"name":"AMRA Medical AB  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Kusama","sequence":"additional","affiliation":[{"name":"Department of Radiology National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiya","family":"Ogata","sequence":"additional","affiliation":[{"name":"Drug Metabolism &amp; Pharmacokinetics Research Laboratories Daiichi Sankyo, Co. Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Mukasa","sequence":"additional","affiliation":[{"name":"Translational Science Department II Daiichi Sankyo, Co. Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kiyosawa","sequence":"additional","affiliation":[{"name":"Translational Science Department II Daiichi Sankyo, Co. Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Radiology National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Widholm","sequence":"additional","affiliation":[{"name":"AMRA Medical AB  Link\u00f6ping Sweden"},{"name":"Department of Radiology and Department of Health, Medicine and Caring Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Center for Medical Image Science and Visualization (CMIV) Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Dahlqvist Leinhard","sequence":"additional","affiliation":[{"name":"AMRA Medical AB  Link\u00f6ping Sweden"},{"name":"Center for Medical Image Science and Visualization (CMIV) Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Health, Medicine and Caring Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Ahlgren","sequence":"additional","affiliation":[{"name":"AMRA Medical AB  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Mori\u2010Yoshimura","sequence":"additional","affiliation":[{"name":"National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0186-x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40674-020-00169-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20958"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114273"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.153.1.6089263"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.17849"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00242-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26813"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200776"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/ICPR.2008.4761764"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21603"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4581"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22580"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200757"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27638"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.08.007"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24726"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz229"},{"issue":"1","key":"e_1_2_11_20_1","first-page":"1","article-title":"Longitudinal study of MRI and functional outcome measures in facioscapulohumeral muscular dystrophy","volume":"22","author":"Wang LH","year":"2021","journal-title":"BMC Musculoskelet Disord"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008939"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009012"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26521"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7047.1654"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5256"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7049.106"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-022-00217-1"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-180333"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8350-6"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24661"},{"key":"e_1_2_11_32_1","volume-title":"Whole Body MRI Quantitative Muscle Analysis to Evaluate Efficacy of Losmapimod in a Phase 2 Placebo\u2010Controlled Study in Subjects with FSHD (ReDUX4): ReDUX4 (NCT04003974)","author":"Tawil R","year":"2021"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192495"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28360"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.28252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T13:21:21Z","timestamp":1733836881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.28252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/mus.28252"],"URL":"https:\/\/doi.org\/10.1002\/mus.28252","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,24]]},"assertion":[{"value":"2023-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}