{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:17:55Z","timestamp":1780319875904,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Assessing upper limb muscle strength is important for understanding health outcomes, such as daily function and mortality. Ultrasound (US) is increasingly used to evaluate muscle health, but the relationship between its measures of morphology and isometric strength has not been thoroughly explored in upper limb muscles. The aim of this study was to evaluate the associations between US morphological measures and isometric strength in functionally relevant upper limb muscles in healthy adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four healthy volunteers (30.0\u2009\u00b1\u200910.8\u2009years) underwent B\u2010mode, axial US scans of the first dorsal interosseus (FDI), flexor pollicis longus (FPL), biceps brachii (BB), brachialis (BR), and triceps brachii lateral head (TB). Participants performed corresponding maximal voluntary contractions (MVC), including first digit distal phalanx flexion, second digit abduction, and elbow flexion and extension. US images were segmented to obtain maximal muscle thickness (MT) and cross\u2010sectional area (CSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Strong positive correlations were found between muscle strength and BB MT (<jats:italic>r<\/jats:italic>\u2009=\u2009.83; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), BR CSA (<jats:italic>r<\/jats:italic>\u2009=\u2009.84; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and TB MT (<jats:italic>r<\/jats:italic>\u2009=\u2009.70; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Moderate positive correlations were found for strength and FDI CSA (<jats:italic>r<\/jats:italic>\u2009=\u2009.67; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), FDI MT (<jats:italic>r<\/jats:italic>\u2009=\u2009.47; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), FPL CSA (<jats:italic>r<\/jats:italic>\u2009=\u2009.54; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), and FPL MT (<jats:italic>r<\/jats:italic>\u2009=\u2009.42; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). No significant correlation was found between strength and BR MT (<jats:italic>r<\/jats:italic>\u2009=\u2009.16; <jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our data showed moderate\u2010to\u2010strong associations between US muscle morphology and strength, suggesting that US is likely a good biomarker for strength. However, its use is not \u201cone size fits all.\u201d Future investigations should continue to assess this relationship in different muscles and expand the generalizability to clinical populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28297","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T09:10:04Z","timestamp":1731057004000},"page":"73-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The strength of associations between ultrasound measures of upper limb muscle morphology and isometric muscle strength: <scp>An<\/scp> exploratory study"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4514-7086","authenticated-orcid":false,"given":"Christina Q. Y.","family":"Whang","sequence":"first","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Experimental Medicine, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew I. B.","family":"Debenham","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Division of Physical Medicine &amp; Rehabilitation, Department of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Ogalo","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah J.","family":"Ro","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Wu","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Berger","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Experimental Medicine, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Division of Physical Medicine &amp; Rehabilitation, Department of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.06.015"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.008295"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0838.2003.00298.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113501327"},{"issue":"3","key":"e_1_2_12_6_1","article-title":"Measuring muscle strength in neurological disorders","volume":"16","author":"Bohannon R. 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