{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:02:59Z","timestamp":1745294579432,"version":"3.40.4"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100023360","name":"St Vincent's Hospital Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Electrophysiological investigations in early Guillain\u2010Barr\u00e9 Syndrome (GBS) can be nondiagnostic. Improved testing for facial weakness in the early phase of GBS may improve diagnostic processes, as such weakness is found in approximately 50% of patients with GBS. This work pilots the utility of high\u2010speed video analysis to complement blink reflex testing in early GBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This work prospectively evaluated consecutive patients admitted to a metropolitan teaching hospital in Melbourne, Australia, with suspected acute GBS within the first 14\u2009days of neurological symptoms and compared them to a cohort of healthy controls. Blink reflex testing, mechanically\u2010activated masseter reflexes, and analysis of high\u2010speed video recordings of the evoked blinks were performed at admission (day 0), day 7, and day 21 (\u00b12\u2009days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>19 suspected GBS patients (12 GBS and 7 mimics) were compared to 22 healthy controls. At the first test, 83% of GBS patients and 29% of mimics demonstrated blink reflex abnormalities. 50% of GBS manifested video abnormalities (14% mimics), but abnormalities preceded electrophysiological changes in two GBS patients. The calculated reference values for peak lid velocity and lid excursion by video analysis were ~160\u2009mm\/s and 7\u20138\u2009mm, respectively, with slightly different values for ipsilateral versus contralateral responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Combining high\u2010speed video analysis and blink reflex testing improves the detection of facial involvement in early GBS and helps discriminate from mimic disorders. Further work in a larger cohort is required to validate the sensitivity and specificity of this technique.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28332","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T10:39:54Z","timestamp":1735900794000},"page":"429-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010Speed Video Blink Analysis Improves Detection of Facial Palsy in Early Guillain\u2010Barr\u00e9 Syndrome"],"prefix":"10.1002","volume":"71","author":[{"given":"Antony","family":"Winkel","sequence":"first","affiliation":[{"name":"Department of Medicine, St Vincent's Hospital Melbourne The University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Neurosciences Sunshine Coast Hospital and Health Service  Birtinya Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent's Hospital Melbourne The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent's Hospital Melbourne The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent's Hospital Melbourne The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2014-000937"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12241"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25250"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2023.02.178"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.05.009"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt285"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000001122"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307815"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27803"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.28332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T14:26:34Z","timestamp":1745245594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.28332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/mus.28332"],"URL":"https:\/\/doi.org\/10.1002\/mus.28332","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"type":"print","value":"0148-639X"},{"type":"electronic","value":"1097-4598"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"2024-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}