{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:00:51Z","timestamp":1775674851352,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>An increased risk of low trauma fractures is well documented in children and adolescents with duchenne muscular dystrophy (DMD). There is limited evidence regarding the fracture incidence of adults with DMD. The aim of this study was to examine radiologically confirmed fractures in adults with DMD and review bone health monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective review of all adult males \u2265\u200916\u2009years with DMD under the care of adult physicians in the West of Scotland (2013\u20132022). Information regarding fractures, bone health monitoring, and bisphosphonate therapy was collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six men (median age at first visit 18.8\u2009years) with DMD were included. Twelve were taking corticosteroids at first review, and a further 12 had previously been taking corticosteroids that were discontinued in childhood or adolescence. The fracture incidence rate was higher in the corticosteroid group (888.9 per 10,000 person years (95% CI 242.2\u20132275.9)) than in those not on corticosteroids (156.3 per 10,000 person years (95% CI 32.2\u2013456.6)). Eighteen had lateral spine radiographs for vertebral fracture assessment and 15 had a DXA scan for bone density assessment during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The fracture incidence in adult men with DMD is more than double that of UK men aged 18\u201349\u2009years old, with an even higher incidence in those treated with corticosteroids. Fewer than half of the study population underwent bone monitoring. There is a need for enhanced clinical guidance for the monitoring and management of osteoporosis during transition and throughout adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28355","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T08:29:04Z","timestamp":1737620944000},"page":"558-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Incidence of Radiologically Confirmed Fractures in Adults With Duchenne Muscular Dystrophy"],"prefix":"10.1002","volume":"71","author":[{"given":"Gavin","family":"Langlands","sequence":"first","affiliation":[{"name":"Institute of Neurological Sciences, Queen Elizabeth University Hospital  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0815-1800","authenticated-orcid":false,"given":"Jennifer","family":"McKechnie","sequence":"additional","affiliation":[{"name":"Bone, Endocrine, Nutrition Research Group in Glasgow, Human Nutrition, University of Glasgow  Glasgow UK"},{"name":"Department of Paediatric Endocrinology Royal Hospital for Children  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E.","family":"Farrugia","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, Queen Elizabeth University Hospital  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sze Choong","family":"Wong","sequence":"additional","affiliation":[{"name":"Bone, Endocrine, Nutrition Research Group in Glasgow, Human Nutrition, University of Glasgow  Glasgow UK"},{"name":"Department of Paediatric Endocrinology Royal Hospital for Children  Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012910"},{"issue":"5","key":"e_1_2_11_3_1","article-title":"Corticosteroids for the Treatment of Duchenne Muscular Dystrophy","volume":"2016","author":"Matthews E.","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9875"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-230176"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2018.09.005"},{"issue":"6","key":"e_1_2_11_7_1","first-page":"701","article-title":"Fractures and Linear Growth in a Nationwide Cohort of Boys With Duchenne Muscular Dystrophy With and Without Glucocorticoid Treatment: Results From the UK NorthStar Database","volume":"76","author":"Joseph S.","year":"2019","journal-title":"Journal of the American Medical Association Neurology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.11.078"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16267"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2024.05.007"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30024-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30025-5"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-200609"},{"key":"e_1_2_11_14_1","unstructured":"\u201cHR. 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