{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:42:14Z","timestamp":1785865334668,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012066","name":"Wings for Life","doi-asserted-by":"publisher","award":["GR024775"],"award-info":[{"award-number":["GR024775"]}],"id":[{"id":"10.13039\/100012066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010843","name":"Foundation for Physical Medicine and Rehabilitation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Cervical spinal cord injury (SCI) significantly impairs upper limb function, affecting patients' quality of life. Nerve transfer surgery can restore arm and hand function, but its success depends on the health of infralesional lower motor neurons (LMNs). LMN abnormalities are prevalent in muscles targeted for nerve transfer, particularly those innervated by the posterior interosseous nerve (PIN) and radial nerve, essential for wrist extension and hand opening. This study evaluates the health of infralesional LMNs in cervical SCI using multipoint stimulation motor unit number estimation (MPS\u2010MUNE). We assessed motor unit counts in the C7\u2010innervated anconeus and the predominantly C8\u2010innervated extensor indicis (EI) to determine their viability as targets for nerve transfer surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, two\u2010center cohort study using MPS\u2010MUNE to evaluate 15 individuals with cervical SCI (26 limbs) and 17 healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compound muscle action potential (CMAP) and MUNE values were significantly lower in SCI patients compared to controls (EI CMAP: 2.0\u2009mV\u2009\u00b1\u20091.57, EI MUNE: 33\u2009\u00b1\u200930.5; anconeus CMAP: 2.7\u2009mV\u2009\u00b1\u20091.9, anconeus MUNE: 39\u2009\u00b1\u200950.6 versus controls: EI CMAP: 6.6\u2009mV\u2009\u00b1\u20091.0, EI MUNE: 137\u2009\u00b1\u200933.9; anconeus CMAP: 6.6\u2009mV\u2009\u00b1\u20091.3, anconeus MUNE: 146\u2009\u00b1\u200942.3). Test\u2013retest reliability for EI and anconeus were 0.84 (CI: 0.45\u20130.95) and 0.78 (CI: 0.36\u20130.93), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Significant LMN loss was observed after cervical SCI. MPS\u2010MUNE shows potential for evaluating LMN health, highlighting its importance for assessing nerve transfer targets and planning interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.28373","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:43:11Z","timestamp":1740530591000},"page":"979-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multipoint Stimulation Motor Unit Number Estimation of the Extensor Indicis and Anconeus After Spinal Cord Injury"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7541-5975","authenticated-orcid":false,"given":"Adenike A.","family":"Adewuyi","sequence":"first","affiliation":[{"name":"Regenerative Neurorehabilitation Laboratory Shirley Ryan AbilityLab  Chicago Illinois USA"},{"name":"Physical Medicine and Rehabilitation Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Ken &amp; Ruth Davee Department of Neurology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-8840","authenticated-orcid":false,"given":"Mahdis","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Vancouver Island Health Authority  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5278-6810","authenticated-orcid":false,"given":"Shreyaa","family":"Khanna","sequence":"additional","affiliation":[{"name":"Regenerative Neurorehabilitation Laboratory Shirley Ryan AbilityLab  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Berger","sequence":"additional","affiliation":[{"name":"Vancouver Island Health Authority  Vancouver British Columbia Canada"},{"name":"International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Division of Physical Medicine &amp; Rehabilitation, Department of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin K.","family":"Franz","sequence":"additional","affiliation":[{"name":"Regenerative Neurorehabilitation Laboratory Shirley Ryan AbilityLab  Chicago Illinois USA"},{"name":"Physical Medicine and Rehabilitation Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Ken &amp; Ruth Davee Department of Neurology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31143-2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.43890"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1310\/sci2403-275"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2022.0181"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7579"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.34.2.121"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.2.868"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21680"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.04.748"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26391"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26839"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.953173"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.7"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2463-4"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141208"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(93)90130-H"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27487"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.28053"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00313625"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968310368534"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-424X(08)00013-5"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21707"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318225aabf"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24092"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25982"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.03.045"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.01.002"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.28373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T08:04:50Z","timestamp":1746691490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.28373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/mus.28373"],"URL":"https:\/\/doi.org\/10.1002\/mus.28373","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.08.08.24311675","asserted-by":"object"}]},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"2023-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}