{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:40:56Z","timestamp":1793911256925,"version":"4.8.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Ataxia\u2010telangiectasia (A\u2010T) is a genetic multisystem neurodegenerative disorder characterized by cerebellar ataxia, oculocutaneous telangiectasia, extrapyramidal involvement, peripheral sensorimotor neuropathy, immunodeficiency, pulmonary disease, and an increased risk of malignancy that ultimately determines the shortened lifespan in many patients. A\u2010T nerve ultrasonographic characteristics remain underexplored. This pilot study aimed to characterize the ultrasonographic morphology of peripheral nerves in patients with A\u2010T.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ultrasound cross\u2010sectional areas (CSAs) of the median, ulnar, sural, and tibial nerves were obtained from three A\u2010T patients and were compared to reference values. Nerve conduction studies and electromyography were also performed. Given the small sample size and the exploratory nature of this study, formal statistical analyses were not performed, and descriptive statistics were presented for the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nerve CSAs in A\u2010T patients were smaller than in healthy controls at all measurement sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Nerve ultrasound revealed atrophy in the peripheral nerves of A\u2010T patients. This reduction in nerve size may distinguish A\u2010T and highlights the utility of nerve ultrasound as a non\u2010invasive diagnostic tool for peripheral sensorimotor neuropathy. These findings may have important implications for early detection in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.28396","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T23:28:56Z","timestamp":1741994936000},"page":"1091-1095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nerve Ultrasound Detects Nerve Atrophy in Patients With Ataxia\u2010Telangiectasia: A Pilot Study"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1213-1687","authenticated-orcid":false,"given":"Antonio E.","family":"Camelo\u2010Filho","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Clinical Medicine Universidade Federal do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L. G. S. B.","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Medicine Universidade Federal do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6664-9012","authenticated-orcid":false,"given":"Rodrigo F.","family":"da Rosa","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Medicine Universidade Federal do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tito B. S.","family":"Soares","sequence":"additional","affiliation":[{"name":"Center of Health Sciences, Universidade Estadual do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 L. S.","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Medicine Universidade Federal do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"},{"name":"Albert Sabin Hospital  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo R.","family":"N\u00f3brega","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Medicine Universidade Federal do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Braga\u2010Neto","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Clinical Medicine Universidade Federal do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"},{"name":"Center of Health Sciences, Universidade Estadual do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1810570"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2019-002253"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/AOMD.AOMD_28_19"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-016-0543-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000224878.22821.23"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13052"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16028"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22016"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09641-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27934"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.12.010"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.09.114"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25476"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13563"},{"key":"e_1_2_11_17_1","first-page":"1","article-title":"ATM Expression Patterns Suggest a Contribution From the Peripheral Nervous System to the Phenotype of Ataxia\u2010Telangiectasia","volume":"7","author":"Soares H. 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