{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:41:53Z","timestamp":1768016513908,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24DC06312"],"award-info":[{"award-number":["K24DC06312"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DC019179"],"award-info":[{"award-number":["K23DC019179"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15DC018944"],"award-info":[{"award-number":["R15DC018944"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32DC020896"],"award-info":[{"award-number":["F32DC020896"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"ALS Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>There is a substantial need to establish reliable approaches for low\u2010burden at\u2010home monitoring of respiratory function for people with amyotrophic lateral sclerosis (PALS). This preliminary study assessed the potential of acoustic features extracted from a smartphone passage reading task to serve as clinically meaningful outcome measures reflecting instrumental and self\u2010reported respiratory function measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six PALS completed an in\u2010clinic slow vital capacity (SVC) task, followed by at\u2010home completion of surveys and audio recording of a reading passage using a smartphone application. Speaking rate and pause features were extracted offline. Correlation analysis evaluated the relationship between the acoustic features and both instrumental (SVC) and self\u2010reported (respiratory subscale of the self\u2010entry version of the ALS Functional Rating Scale\u2010Revised; ALSFRS\u2010RSE) measures of respiratory function. Receiver operator characteristic (ROC) with area under the curve (AUC) analysis evaluated the utility of acoustic features for classifying participants with and without respiratory involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SVC and respiratory self\u2010ratings were significantly correlated with pause, but not rate, measures. Percent pause time was the most strongly correlated acoustic feature with both SVC (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.62) and ALSFRS\u2010RSE respiratory subscale ratings (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.43). ROC analysis revealed that percent pause time classified participants presenting with respiratory involvement based on instrumentation (SVC &lt;\u200970% predicted [AUC\u2009=\u20090.70]; SVC &lt;\u200950% predicted [AUC\u2009=\u20090.88]) and self\u2010ratings when using the respiratory ALSFRS\u2010RSE score cut\u2010off of &lt;\u200911 (AUC\u2009=\u20090.78), but not &lt;\u200912 (AUC\u2009=\u20090.61).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Percent pause time, extracted from a smartphone\u2010recorded passage reading, offers a promising index for remote assessment and monitoring of respiratory function in PALS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28435","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:46:35Z","timestamp":1747201595000},"page":"321-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Preliminary Investigation of Acoustic Features for Remote Monitoring of Respiration in <scp>ALS<\/scp>"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0849-1441","authenticated-orcid":false,"given":"Kathryn P.","family":"Connaghan","sequence":"first","affiliation":[{"name":"Speech and Social Interaction Lab MGH Institute of Health Professions  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-6521","authenticated-orcid":false,"given":"Marziye","family":"Eshghi","sequence":"additional","affiliation":[{"name":"Speech, Physiology, and Neurobiology of Aging and Dementia Lab MGH Institute of Health Professions  Boston Massachusetts USA"},{"name":"Athinoula A. Martinos Centre for Biomedical Imaging  Boston Massachusetts USA"},{"name":"Department of Radiology, MGH Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6758-9791","authenticated-orcid":false,"given":"Abigail E.","family":"Haenssler","sequence":"additional","affiliation":[{"name":"Speech and Social Interaction Lab MGH Institute of Health Professions  Boston Massachusetts USA"},{"name":"Speech and Feeding Disorders Lab MGH Institute of Health Professions  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1464-1373","authenticated-orcid":false,"given":"Jordan R.","family":"Green","sequence":"additional","affiliation":[{"name":"Speech and Feeding Disorders Lab MGH Institute of Health Professions  Boston Massachusetts USA"},{"name":"Program in Speech and Hearing Bioscience and Technology Harvard University  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joycelyn","family":"Wang","sequence":"additional","affiliation":[{"name":"Speech and Social Interaction Lab MGH Institute of Health Professions  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-9368","authenticated-orcid":false,"given":"Zoe","family":"Scheier","sequence":"additional","affiliation":[{"name":"Healey Center for ALS, Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mackenzie","family":"Keegan","sequence":"additional","affiliation":[{"name":"Healey Center for ALS, Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Clark","sequence":"additional","affiliation":[{"name":"Healey Center for ALS, Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6613-8668","authenticated-orcid":false,"given":"Jukka\u2010Pekka","family":"Onnela","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard University  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5820-5880","authenticated-orcid":false,"given":"Katherine M.","family":"Burke","sequence":"additional","affiliation":[{"name":"Healey Center for ALS, Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"MGH Institute of Health Professions  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0898-6081","authenticated-orcid":false,"given":"James D.","family":"Berry","sequence":"additional","affiliation":[{"name":"Healey Center for ALS, Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School, School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.770"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2018.1541095"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2196\/31877"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746\u2010020\u201000335\u2010x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2019.1587633"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.122971"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2018.1452945"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0248\u20102022"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2021.1915337"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","unstructured":"K. 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