{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:35:04Z","timestamp":1785893704764,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\/NIA R44AG074840"],"award-info":[{"award-number":["NIH\/NIA R44AG074840"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>This study examined the potential of multi\u2010frequency electrical impedance myography (EIM) to predict hand grip strength (HGS) variability among adults, including a large proportion of older adults, with and without sarcopenia. The objective was to develop predictive models using EIM data for assessing HGS and to explore its potential use in clinical evaluations of muscle function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010three participants aged 18\u201393\u2009years were recruited at community events, with 69 completing EIM and HGS assessments. EIM data were collected from the forearm flexor and extensor muscle groups, and regression techniques, including Lasso regression, were applied to develop predictive models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Approximately 60% of participants were over 65\u2009years old, and 23% exhibited HGS values below sarcopenia thresholds. EIM measurements explained 48% of the variance in HGS. Adding demographic factors (sex, age, BMI) improved the explained variance to 64%, highlighting EIM's potential in muscle health assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The findings suggest that multi\u2010frequency EIM shows potential as a non\u2010invasive tool for predicting HGS and assessing muscle function, particularly in aging populations. Further research is needed to fully establish EIM's utility in clinical settings for the early detection and management of sarcopenia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28449","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T01:44:52Z","timestamp":1749001492000},"page":"416-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multi\u2010Frequency Electrical Impedance Myography as a Predictor of Muscle Function in Older Adults"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-1172","authenticated-orcid":false,"given":"Niladri Kumar","family":"Mahato","sequence":"first","affiliation":[{"name":"Department of Anatomy, Tom &amp; Julie Wood College of Osteopathic Medicine Marian University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buket Sonbas","family":"Cobb","sequence":"additional","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Electrical and Electronic Engineering Harran University  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6375-3312","authenticated-orcid":false,"given":"Seward B.","family":"Rutkove","sequence":"additional","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. David","family":"Arnold","sequence":"additional","affiliation":[{"name":"NextGen Precision Medicine University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-6431","authenticated-orcid":false,"given":"Brian C.","family":"Clark","sequence":"additional","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute Ohio University  Athens Ohio USA"},{"name":"Department of Biomedical Sciences Ohio University Heritage College of Osteopathic Medicine  Athens Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169548"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs194"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2018.47"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.10.016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00087"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.666964"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24270"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a034405"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.04.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24874"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.10.030"},{"key":"e_1_2_10_14_1","first-page":"514","article-title":"The Effect of Profound Dehydration on Electrical Impedance of Mouseskeletal Muscle","volume":"2014","author":"Jia L.","year":"2014","journal-title":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa157"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1675-4"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-014-3838-8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00420.2020"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1996.tb02080.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-84858-7"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27963"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26187"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26111"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27095"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27240"},{"issue":"7","key":"e_1_2_10_26_1","article-title":"Surface Electrical Impedance Myography Detects Skeletal Muscle Atrophy in Aged Wildtype Zebrafish and Aged gpr27 Knockout Zebrafish","volume":"11","author":"Rutkove S. B.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-7138-7"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.07.023"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab098"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20626"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12238"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029785"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77064-2_32"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00070.2003"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13300"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-022-02898-8"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/jmu.jmu_28_22"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.27.2147"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glae056"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2023.112278"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.28449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T14:14:00Z","timestamp":1754921640000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.28449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/mus.28449"],"URL":"https:\/\/doi.org\/10.1002\/mus.28449","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"assertion":[{"value":"2025-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}