{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:00:51Z","timestamp":1755223251571,"version":"3.43.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009800","name":"Stiftelsen Professor Nanna Svartz Fond","doi-asserted-by":"publisher","award":["2023\u2010025"],"award-info":[{"award-number":["2023\u2010025"]}],"id":[{"id":"10.13039\/501100009800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007857","name":"Stiftelsen Konung Gustaf V:s 80-\u00e5rsfond","doi-asserted-by":"publisher","award":["FAI\u20102022\u20100891"],"award-info":[{"award-number":["FAI\u20102022\u20100891"]}],"id":[{"id":"10.13039\/501100007857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Idiopathic inflammatory myopathies (IIMs) are classified into five subtypes that are associated with distinct groups of myositis\u2010specific antibodies (MSAs). Variations in the prevalence, genetic predisposition and clinical manifestations exist in patients with IIM from different ethnic backgrounds. In this study, we aimed to characterize the immunopathological changes in muscle tissue and serum cytokines in a Vietnamese IIM cohort with Kinh ethnicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Muscle biopsies, sera, clinical data, and autoantibody profiles from 64 patients with IIM were included. Muscles were stained by immunohistochemistry using antibodies that target immune cells and molecules. Serum cytokines were measured by multiplex bead arrays. Clustering analysis was performed using the partitioning around medoids algorithm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The anti\u2010MDA5 antibody was the most common MSA in this cohort (15.6%), followed by anti\u2010Jo\u20101 (10.9%). A wide range of clinical manifestations and immunohistological features were seen within the serologically defined subgroups. There was no difference in the levels of immune cells, capillary density or dilation, or patterns of C5b\u20109 expression between the myositis subgroups. MHC\u2010I patterns were the only immunomorphological variable that was different in these subgroups. IP\u201010, IL\u201017A, and APRIL were increased in patients with IIM compared to healthy controls (<jats:italic>p<\/jats:italic>\u2009=\u20095.7\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>, 6.9\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>, 2.4\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>, respectively) but without difference between IIM subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Vietnamese patients with IIM demonstrated widely varying clinical and immunopathological features, with dermatomyositis and immune\u2010mediated necrotizing myopathy representing opposite ends of MHC\u2010I upregulation in muscle tissue. Thus classification of myositis requires comprehensive evaluation of clinical manifestations, serology profiling and muscle pathology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28455","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T08:23:09Z","timestamp":1750062189000},"page":"464-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune Characterization of a Vietnamese Cohort With Idiopathic Inflammatory Myopathies"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-0154","authenticated-orcid":false,"given":"Yue\u2010Bei","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Neurology Xiangya Hospital, Central South University  Changsha China"},{"name":"Research Center for Neuroimmune and Neuromuscular Disorders Xiangya Hospital, Central South University  Changsha China"},{"name":"Division of Rheumatology, Department of Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Molecular Medicine Karolinska Institutet, Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-5373","authenticated-orcid":false,"given":"Maho","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Molecular Medicine Karolinska Institutet, Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nham Pham Thi","family":"Minh","sequence":"additional","affiliation":[{"name":"Rheumatology Department Bach Mai Hospital  Hanoi Vietnam"},{"name":"Internal Medicine Department Hanoi Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9460-8639","authenticated-orcid":false,"given":"L\u00e9o","family":"Heinon","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Ma\u00efeutique et Sciences de la Sant\u00e9, Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Nennesmo","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Pathology and Cancer Diagnostics Karolinska University Hospital Solna  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1186-3226","authenticated-orcid":false,"given":"Johan","family":"R\u00f6nnelid","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6068-9212","authenticated-orcid":false,"given":"Ingrid E.","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Center for Molecular Medicine Karolinska Institutet, Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy Nguyen Thi","family":"Phuong","sequence":"additional","affiliation":[{"name":"Rheumatology Department Bach Mai Hospital  Hanoi Vietnam"},{"name":"Internal Medicine Department Hanoi Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2241-5170","authenticated-orcid":false,"given":"Begum","family":"Horuluoglu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine Karolinska 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