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This study describes the prevalence of cancer among individuals diagnosed with DM from the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet), and compares it to cancer prevalence in the US Surveillance, Epidemiology, and End Result (SEER) data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study used 2008\u20132019 medical records data on 1229 individuals diagnosed with DM (DM1: 81.4%, DM2: 9.4%, DM\u2010not otherwise specified [NOS]: 9.2%) from MD STARnet. Age\u2010 and sex\u2010specific cancer prevalence rates from SEER were applied to the MD STARnet data to calculate 12\u2010year limited duration (LD) and complete standardized prevalence ratios (SPR) for total cancer and by primary cancer site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a 12\u2010year span, individuals with DM1 had a 4.01\u2010fold higher LD prevalence of thyroid cancer and a 17.97\u2010fold higher LD prevalence of nonmelanoma skin cancer compared to the SEER prevalence, respectively. Complete prevalence assessments identified that individuals with DM1 had a 4.18\u2010fold higher prevalence of thyroid cancer, a 2.36\u2010fold higher prevalence of melanoma, and a 4.68\u2010fold higher prevalence of ovarian cancer. For DM2, the study observed a 34.02\u2010fold higher LD prevalence for nonmelanoma skin cancer. Additionally, a significantly elevated complete prevalence of breast cancer (2.65\u2010fold) was noted for DM2 compared to SEER data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Future research with larger cohorts is needed to define cancer risks by DM subtype and investigate underlying biological mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28464","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T12:03:14Z","timestamp":1752408194000},"page":"570-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Elevated Cancer Prevalence Identified at Specific Anatomical Sites Among People With Myotonic Dystrophy Using a Population\u2010Based Sample"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8328-1551","authenticated-orcid":false,"given":"Wanfang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of South Carolina  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Bhandaru","sequence":"additional","affiliation":[{"name":"Biostatistics Center George Washington University  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-4257","authenticated-orcid":false,"given":"Nicholas E.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Moore","sequence":"additional","affiliation":[{"name":"RTI International  Research Triangle Park North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Environmental, Occupational, and Geospatial Health Sciences, Graduate School of Public Health &amp; Health Policy City University of New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reba","family":"Berry","sequence":"additional","affiliation":[{"name":"Division of Population Health Surveillance, Department of Health Bureau of Maternal and Child Health  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Westfield","sequence":"additional","affiliation":[{"name":"Division of Population Health Surveillance, Department of Health Bureau of Maternal and Child Health  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-4036","authenticated-orcid":false,"given":"Daria","family":"McMahon","sequence":"additional","affiliation":[{"name":"Division of Population Health Surveillance, Department of Health Bureau of Maternal and Child Health  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Soim","sequence":"additional","affiliation":[{"name":"New York State Department of Health  Albany New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of South Carolina  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Environmental, Occupational, and Geospatial Health Sciences, Graduate School of Public Health &amp; 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