{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:57:46Z","timestamp":1758056266410,"version":"3.44.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100003157","name":"Myasthenia Gravis Foundation of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003157","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Patients with myasthenia gravis (MG) often receive immunosuppressive treatments. While approved COVID\u201019 vaccines effectively prevent severe infections, the impact of vaccination among immunocompromised MG patients remains unclear. This study explored vaccination status, adverse events, and post\u2010vaccination outcomes among MG patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A REDCap survey was conducted between September 21, 2021 and November 18, 2021 through the Myasthenia Gravis Foundation of America to collect data on demographic and disease characteristics, COVID\u201019 infections, vaccination status, and precaution strategies. A follow\u2010up survey was available from January 11, 2022 to March 8, 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1205 participants [65.7% female, average age 59.6\u2009\u00b1\u200915.4\u2009years] completed the survey. Most were White or Caucasian (87.9%), 63.6% held a bachelor's degree or higher, and 41.9% were retired. Acetylcholine receptor (AChR) antibody positivity was reported by 47%, MuSK\u2010Ab positivity by 6.1%, and 19.6% were seronegative. Most (75%) were on immunosuppressive therapy, and the vaccination rate was 91.5%. Among COVID\u201019 vaccine recipients, 61.5% reported adverse effects, while 8.5% of participants remained unvaccinated due to concerns about side effects (65%) and potential worsening of MG symptoms (70.9%). Post\u2010vaccination COVID\u201019 infection rates dropped from 9.7% to 2.4%. Hospitalization decreased from 2.3% to 0.3%, and MG exacerbation rates from 5.5% to 1.4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>COVID\u201019 vaccination acceptance is high among MG patients. Reported side effects in MG patients were comparable to those in the general population, and vaccination was associated with a reduced COVID\u201019 infection rate. Addressing concerns about vaccine side effects and providing efficacy data specific to MG could aid unvaccinated individuals in decision\u2010making.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28466","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T08:28:53Z","timestamp":1752136133000},"page":"597-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>COVID<\/scp>\u201019 Vaccination and Infection in Myasthenia Gravis: A Longitudinal Patient Survey"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9019-3728","authenticated-orcid":false,"given":"Yingkai","family":"Li","sequence":"first","affiliation":[{"name":"Neuromuscular Division, Department of Neurology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2773-2506","authenticated-orcid":false,"given":"Srikanth","family":"Muppidi","sequence":"additional","affiliation":[{"name":"Department of Neurology Stanford Medical Center  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakthi","family":"Unnithan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein R.","family":"Al\u2010Khalidi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Masterson","sequence":"additional","affiliation":[{"name":"Myasthenia Gravis Foundation of America  Westborough Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendi","family":"Huff","sequence":"additional","affiliation":[{"name":"Myasthenia Gravis Foundation of America  Westborough Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vern C.","family":"Juel","sequence":"additional","affiliation":[{"name":"Neuromuscular Division, Department of Neurology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey T.","family":"Guptill","sequence":"additional","affiliation":[{"name":"Neuromuscular Division, Department of Neurology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0216-1564","authenticated-orcid":false,"given":"Shruti M.","family":"Raja","sequence":"additional","affiliation":[{"name":"Neuromuscular Division, Department of Neurology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_12_2_1","DOI":"10.1016\/S1474-4422(20)30413-0"},{"unstructured":"Accessed June 15 2022 https:\/\/myasthenia.org\/Newly\u2010Diagnosed\/Cautionary\u2010Drugs\u2010for\u2010MG\u2010Patients.","key":"e_1_2_12_3_1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_4_1","DOI":"10.1002\/mus.26689"},{"doi-asserted-by":"publisher","key":"e_1_2_12_5_1","DOI":"10.1136\/annrheumdis-2021-220604"},{"key":"e_1_2_12_6_1","article-title":"Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS\u2010CoV\u20102","author":"Deepak P.","year":"2021","journal-title":"Medrxiv"},{"doi-asserted-by":"publisher","key":"e_1_2_12_7_1","DOI":"10.1016\/j.jbi.2008.08.010"},{"unstructured":"Vaccine Confidence Survey Question Bank [Online] https:\/\/caiglobal.org\/wp\u2010content\/uploads\/2022\/10\/Vaccine\u2010Confidence\u2010Survey\u2010Question\u2010Bank\u2010508.pdf. accessed July 21 2021.","key":"e_1_2_12_8_1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_9_1","DOI":"10.1002\/mus.27130"},{"doi-asserted-by":"publisher","key":"e_1_2_12_10_1","DOI":"10.17161\/rrnmf.v4i1.18415"},{"doi-asserted-by":"publisher","key":"e_1_2_12_11_1","DOI":"10.1002\/mus.22140"},{"doi-asserted-by":"publisher","key":"e_1_2_12_12_1","DOI":"10.1002\/mus.25198"},{"doi-asserted-by":"publisher","key":"e_1_2_12_13_1","DOI":"10.1056\/NEJMoa2035389"},{"doi-asserted-by":"publisher","key":"e_1_2_12_14_1","DOI":"10.1056\/NEJMoa2034577"},{"doi-asserted-by":"publisher","key":"e_1_2_12_15_1","DOI":"10.1056\/NEJMoa2101544"},{"unstructured":"N. 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