{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T11:07:23Z","timestamp":1774696043071,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Quantitative muscle ultrasound (QMUS) shows promise as a non\u2010invasive biomarker for monitoring functional status in Duchenne muscular dystrophy (DMD). We evaluated the correlation between QMUS in various muscles and functional capacity assessments. Additionally, we compared the utility of composite QMUS scores as a comprehensive measure of disease progression to that of single\u2010muscle analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed baseline data from an ongoing prospective study involving 23 patients with DMD (aged 5\u201318\u2009years; mean 10.7; SD 4.2). High\u2010resolution ultrasound scans of muscle groups across the upper and lower limbs, head and neck, and diaphragm were assessed for muscle echogenicity using mean grayscale values (MGV). Functional capacity assessments included the 6\u2010min\u00a0walk test (6MWT), North Star Ambulatory Assessment (NSAA), Performance of Upper Limb (PUL) module, timed function tests, quantitative muscle strength tests, and respiratory muscle strength tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The composite MGV for upper and lower limbs demonstrated moderate to strong negative correlations with the 6MWT and NSAA scores (correlation coefficient [CC]: \u22120.44 to \u22120.74; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and strong to very strong positive correlations with rise\u2010from\u2010floor, 4\u2010stair climb, and 10\u2010m walk\/run times (CC: 0.65 to 0.87; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). For upper limb function, the MGV of the flexor carpi radialis muscle was negatively correlated with PUL scores (CC\u2009=\u2009\u22120.35, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). However, no significant correlations were observed between QMUS parameters and muscle strength test (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>QMUS offers a non\u2010invasive method for assessing muscle changes and tracking disease progression in DMD.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> identifier: NCT05249361<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28469","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T06:38:59Z","timestamp":1752734339000},"page":"606-615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quantitative Muscle Ultrasound: A Non\u2010Invasive Biomarker for Monitoring Duchenne Muscular Dystrophy"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3284-3024","authenticated-orcid":false,"given":"Yu Jin","family":"Im","sequence":"first","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Samsung Medical Center  Seoul Republic of Korea"},{"name":"Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2059-125X","authenticated-orcid":false,"given":"Yumi","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Samsung Medical Center  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8456-684X","authenticated-orcid":false,"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Department of Pediatrics Samsung Medical Center  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-3307","authenticated-orcid":false,"given":"Jeehun","family":"Lee","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Department of Pediatrics Samsung Medical Center  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8001-7782","authenticated-orcid":false,"given":"Jong Geol","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Samsung Medical Center  Seoul Republic of Korea"},{"name":"Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2011-8834","authenticated-orcid":false,"given":"Jeong\u2010Yi","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Samsung Medical Center  Seoul Republic of Korea"},{"name":"Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31611-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-210689"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.10.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004570"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4155\/cli.11.113"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06085-w"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2020.05.001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815570154"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2002.tb00272.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27762"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.0242"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.04065"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24904"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27081"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00825-1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24296"},{"issue":"13","key":"e_1_2_11_18_1","first-page":"1","article-title":"Duchenne 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