{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:48:05Z","timestamp":1790948885637,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Far field potentials (FFP) have been proposed as a reliable neurophysiological prognostic biomarker in amyotrophic lateral sclerosis (ALS). This study evaluates the diagnostic utility of ulnar nerve FFP in ALS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Comprehensive peripheral neurophysiological assessments were conducted in 62 ALS and 43 ALS\u2010mimicking disorder participants. The ulnar nerve was stimulated at the wrist, recording motor responses over the abductor digit minimi (ADM) muscle. Conventional compound muscle action potentials (CMAP), FFP, and near field potential amplitudes were recorded, alongside the split\u2010hand index, neurophysiological index, motor unit number estimation (MScanFit\u2010MUNE), and motor unit index (MUNIX). Diagnostic utility was evaluated using receiver operating characteristic (ROC) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In ALS, FFP amplitude was significantly lower (5.07\u2009\u00b1\u20090.36\u2009mV) compared to ALS mimics (8.25\u2009\u00b1\u20090.40\u2009mV, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). FFP amplitude exhibited a moderate\u2010to\u2010strong correlation with neurophysiological biomarkers, including CMAP amplitude (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.77, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), split\u2010hand index (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.53, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), neurophysiological index (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.52, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), MUNIX (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.69, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and MScanFit\u2010MUNE (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.66, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Weak\u2010to\u2010moderate correlations were also observed with clinical measures of disease progression, including upper limb muscle strength, ALS functional rating score\u2010revised (ALSFRS\u2010R) and the rate of decline in the ALSFRS\u2010R fine motor subscore. ROC analysis demonstrated that FFP amplitude reliably distinguished ALS from mimicking disorders (AUC\u2009=\u20090.80, 95% CI: 0.71\u20130.89), with consistent diagnostic accuracy across ALS phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The diagnostic capability of FFP amplitude was comparable to established neurophysiological biomarkers utilized in ALS. It is a promising prognostic and diagnostic biomarker for ALS. Its simplicity and reproducibility complement traditional neurophysiological measures, offering potential for clinical application in ALS diagnosis and monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28480","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T09:29:13Z","timestamp":1752830953000},"page":"616-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Utility of Far\u2010Field Potentials in Amyotrophic Lateral Sclerosis"],"prefix":"10.1002","volume":"72","author":[{"given":"Aicee Dawn","family":"Calma","sequence":"first","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Pavey","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4495-6314","authenticated-orcid":false,"given":"Claudia Santos","family":"Silva","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital  Sydney New South Wales Australia"},{"name":"Department of Neurosciences and Mental Health Unidade Local de Sa\u00fade de Santa Maria  Lisbon Portugal"},{"name":"Faculdade de Medicina\u2010Instituto de Medicina Molecular, Centro de Estudos Egas Moniz Universidade de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5805-0631","authenticated-orcid":false,"given":"Yukiko","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital  Sydney New South Wales Australia"},{"name":"Department of Neurology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi A. J.","family":"Van den Bos","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4472-0902","authenticated-orcid":false,"given":"Michelle A.","family":"Farrar","sequence":"additional","affiliation":[{"name":"Department of Neurology Sydney Children's Hospital Network  Sydney New South Wales Australia"},{"name":"Discipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine and Health The University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-5852","authenticated-orcid":false,"given":"Parvathi","family":"Menon","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-873X","authenticated-orcid":false,"given":"Steve","family":"Vucic","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01272-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00434-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2024.04.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2024.04.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820410020600"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2021.06.008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.03.045"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3791\/56805"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.07.025"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26743"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21931"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199903)22:3<378::AID-MUS11>3.0.CO;2-2"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27829"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012799"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.04.005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.12.012"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-310998"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200003)23:3<344::AID-MUS5>3.0.CO;2-N"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.07.021"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21824"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2023.09.018"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26099"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21620"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199901)22:1<6::AID-MUS4>3.0.CO;2-2"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20949"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2012.734521"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.07.022"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200001)23:1<138::AID-MUS22>3.0.CO;2-7"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-980X(97)00037-4"}],"container-title":["Muscle &amp; 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