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Reduced or absent dystrophin expression results in sarcolemmal instability, chronic inflammation, oxidative stress, impaired muscle regeneration, and fibrosis. MicroRNAs (miRNAs) are small non\u2010coding RNAs that regulate gene expression post\u2010transcriptionally and significantly influence multiple pathological processes in DMD. Specific miRNAs, including miR\u2010146a, miR\u2010155, miR\u2010378, and miR\u2010711, modulate inflammation primarily through the NF\u2010\u03baB signaling pathway. Others, such as miR\u201021, miR\u201031, miR\u2010128, miR\u2010144, and miR\u2010379, regulate oxidative stress responses via the NRF2 antioxidant pathway. Muscle\u2010specific miRNAs (myomiRs), notably miR\u20101, miR\u2010133a\/b, miR\u2010206, miR\u2010486, and miR\u2010499, are critical for muscle regeneration, and their dysregulation impairs satellite cell function and muscle repair. 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Understanding the specific roles of these miRNAs provides valuable insights into the molecular mechanisms underlying DMD and may facilitate the identification of novel therapeutic targets.<\/jats:p>","DOI":"10.1002\/mus.28482","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T06:43:17Z","timestamp":1752907397000},"page":"541-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Advances in MicroRNAs in Pathophysiology of Duchenne Muscular Dystrophy"],"prefix":"10.1002","volume":"72","author":[{"given":"Jose Emilio Galeazzi","family":"Aguilar","sequence":"first","affiliation":[{"name":"Laboratorio de Nutrici\u00f3n Molecular, Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Ciudad de M\u00e9xico M\u00e9xico"},{"name":"Posgrado en Ciencias Biom\u00e9diicas, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Almeida\u2010Becerril","sequence":"additional","affiliation":[{"name":"Laboratorio de Nutrici\u00f3n Molecular, Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8496-4023","authenticated-orcid":false,"given":"Maricela","family":"Rodr\u00edguez\u2010Cruz","sequence":"additional","affiliation":[{"name":"Laboratorio de Nutrici\u00f3n Molecular, Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-02996-8"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11796-x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1182524"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01862-w"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2018.tb00051.x"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.09.016"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199802)21:2<173::AID-MUS4>3.0.CO;2-8"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-019-0207-0"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.10.403"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-1162-2"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.921785"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.09.002"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119434"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4689"},{"issue":"3","key":"e_1_2_14_16_1","first-page":"353","article-title":"Expression Profiling in Exercised Mdx Suggests a Role for Extracellular Proteins in the Dystrophic Muscle Immune Response","volume":"19","author":"Coles C. 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