{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:25:35Z","timestamp":1764228335478,"version":"3.46.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Many generic and disease\u2010specific quality of life (QoL) measures have been used to understand the perspectives of patients with myasthenia gravis (MG). However, there is limited data regarding the use of the Individualized Neuromuscular Quality of Life Questionnaire (INQoL) and the impact of body image in patients with MG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional cohort of 258 patients with MG who completed several QoL measures, including the INQoL, 36\u2010Item Short Form Survey (SF\u201036) and 15\u2010Item Myasthenia Gravis Quality of Life Scale (MG\u2010QoL15). We compared scores of different QoL measures with each other and also compared SF\u201036 scores to the general population. Linear regression models were built to investigate factors associated with QoL and body image in MG patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MG patients had lower SF\u201036 scores compared to the general population. Of the different QoL measures, the INQoL correlated the strongest with the MG\u2010QoL15 (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Worse QoL (measured by the INQoL) was significantly correlated with increased disease severity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0054) and fatigue (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0019), younger age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0471), and retirement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0450). Worse INQoL body image scores were significantly associated with increased fatigue (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0189) and ptosis severity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0298).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The INQoL showed that body image is negatively affected in people with MG, suggesting it poses a burden and may be worth considering when measuring QoL. Further studies are needed to assess other factors associated with reduced body image, besides ptosis and fatigue, in people living with MG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70000","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T05:20:07Z","timestamp":1755840007000},"page":"1091-1099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Cross\u2010Sectional Study of Quality of Life and Body Image in Myasthenia Gravis Patients: A Novel Approach Using the Individualized Neuromuscular Quality of Life Questionnaire"],"prefix":"10.1002","volume":"72","author":[{"given":"Michael","family":"Chou","sequence":"first","affiliation":[{"name":"Toronto General Hospital Ellen and Martin Prosserman Centre for Neuromuscular Disease  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meg","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Ellen and Martin Prosserman Centre for Neuromuscular Disease  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4716-3304","authenticated-orcid":false,"given":"Hans","family":"Katzberg","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Ellen and Martin Prosserman Centre for Neuromuscular Disease  Toronto Canada"},{"name":"University Health Network and University of Toronto Division of Neurology  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5805-4883","authenticated-orcid":false,"given":"Vera","family":"Bril","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Ellen and Martin Prosserman Centre for Neuromuscular Disease  Toronto Canada"},{"name":"University Health Network and University of Toronto Division of Neurology  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-0221","authenticated-orcid":false,"given":"Carolina","family":"Barnett\u2010Tapia","sequence":"additional","affiliation":[{"name":"Toronto General Hospital Ellen and Martin Prosserman Centre for Neuromuscular Disease  Toronto Canada"},{"name":"University Health Network and University of Toronto Division of Neurology  Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","unstructured":"Study protocol for the World Health Organization Project to Develop a Quality of Life Assessment Instrument (WHOQOL) \u201cQuality of Life Research: an International Journal of Quality of Life Aspects of Treatment care and rehabilitation \u201d2 no.2(1993):153\u2013159.","DOI":"10.1007\/BF00435734"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20101\u201060"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11082189"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010021\u201010891\u20101"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26719"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760\u2010022\u201001919\u2010y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010023\u201002437\u2010w"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.553626"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"56","article-title":"Hope, Coping, and Quality of Life in Adults With Myasthenia Gravis","volume":"38","author":"Koopman W. 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