{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:31:53Z","timestamp":1791304313262,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceutica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015661","name":"UCB Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Myasthenia gravis (MG) is characterized by fluctuating symptoms, making the assessment of disease activity challenging. Discordance between the clinician\u2010reported quantitative myasthenia gravis (QMG) score and the patient\u2010reported MG activity of daily living (MG\u2010ADL) has previously been observed. We aimed to compare QMG and MG\u2010ADL in a clinical practice setting and to relate to the quality\u2010of\u2010life instrument myasthenia gravis quality of life 15 (MG\u2010QoL\u201015).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      MG patients simultaneously assessed by QMG, MG\u2010ADL, and MG\u2010QoL\u201015 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009177) identified in the Swedish MG registry were included. The distribution of total scores for QMG and MG\u2010ADL and per\u2010item score discordance was investigated using the Chi\u2010squared test and paired t\u2010tests. Multivariate linear regression models were constructed to identify factors associated with QMG and MG\u2010ADL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MG\u2010ADL exhibited a lower floor effect compared to QMG (14% vs. 28%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and patients reported significantly worse scores with MG\u2010ADL than QMG, particularly in bulbar and respiratory items (for breathing item 38% MG\u2010ADL\u2009&gt;\u2009QMG vs. 5% MG\u2010ADL\u2009&lt;\u2009QMG score). Multivariate analysis revealed that new\u2010onset status, MG\u2010QoL\u201015 score, and a history of prednisolone treatment were significantly associated with QMG scores, whereas only MG\u2010QoL\u201015 was significantly associated with MG\u2010ADL. These associations were driven by symptom\u2010associated questions in MG\u2010QoL\u201015, while the emotional well\u2010being questions were associated with neither QMG nor MG\u2010ADL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We observed that MG\u2010ADL more readily identified residual symptoms in patients with mild disease activity compared to QMG; however, with a stronger influence of quality of life, suggesting a complementarity of the two scores in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70013","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T15:18:51Z","timestamp":1756221531000},"page":"1100-1107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the Quantitative Myasthenia Gravis and Myasthenia Gravis Activity of Daily Living Scores From a Clinical Practice Perspective"],"prefix":"10.1002","volume":"72","author":[{"given":"Wanqing","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Neuroimmunology Unit, Center for Molecular Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-0429","authenticated-orcid":false,"given":"Malin","family":"Petersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Neuroimmunology Unit, Center for Molecular Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Piehl","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Neuroimmunology Unit, Center for Molecular Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Neurology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-9488","authenticated-orcid":false,"given":"Susanna","family":"Brauner","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Neuroimmunology Unit, Center for Molecular Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Neurology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0079-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703193161205"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11015.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1487"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207278"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21185"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dc1b1e"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb22937.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000312374.95186.cc"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602489"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.2887"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30369-1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00159-9"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00080-7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00077-7"},{"key":"e_1_2_11_17_1","unstructured":"Myasthenia Gravis Inebilizumab Trial. ClinicalTrials.gov Identifier: NCT04524273. Updated October 8 2024 accessed October 28 2024 https:\/\/clinicaltrials.gov\/study\/NCT04524273."},{"key":"e_1_2_11_18_1","unstructured":"A Study of Nipocalimab Administered to Adults with Generalized Myasthenia Gravis. ClinicalTrials.gov Identifier: NCT04951622. Updated October 9 2024 accessed October 28 2024 https:\/\/clinicaltrials.gov\/study\/NCT04951622."},{"key":"e_1_2_11_19_1","unstructured":"Study of Telitacicept in Generalized Myasthenia Gravis. ClinicalTrials.gov Identifier: NCT05737160. Updated October 12 2023 accessed October 28 2024 https:\/\/clinicaltrials.gov\/study\/NCT05737160."},{"key":"e_1_2_11_20_1","unstructured":"Safety and Efficacy of ALXN1720 in Adults with Generalized Myasthenia Gravis. ClinicalTrials.gov Identifier: NCT05556096. Updated October 15 2024 accessed October 28 2024 https:\/\/clinicaltrials.gov\/study\/NCT05556096."},{"key":"e_1_2_11_21_1","unstructured":"Phase 3 Study to Assess the Efficacy and Safety of Batoclimab as Induction and Maintenance Therapy in Adult Participants with Generalized Myasthenia Gravis. ClinicalTrials.gov identifier: NCT05403541. Updated August 7 2024 accessed October 28 2024 https:\/\/clinicaltrials.gov\/study\/NCT05403541."},{"key":"e_1_2_11_22_1","unstructured":"Reflection Paper on the Regulatory Guidance for the Use of Health\u2010Related Quality of Life (HRQL) Measures in the Evaluation of Medicinal Products European Medicines Agency Web Site. Updated July 27 2005 accessed July 8 2024 https:\/\/www.ema.europa.eu\/en\/regulatory\u2010guidance\u2010use\u2010health\u2010related\u2010quality\u2010life\u2010hrql\u2010measures\u2010evaluation\u2010medicinal\u2010products\u2010scientific\u2010guideline."},{"key":"e_1_2_11_23_1","unstructured":"Guidance for Industry: Patient\u2010Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims. 2009 U.S. Food and Drug Administration Web Site. Updated October 17 2019 accessed July 8 2024 https:\/\/www.fda.gov\/regulatory\u2010information\/search\u2010fda\u2010guidance\u2010documents\/patient\u2010reported\u2010outcome\u2010measures\u2010use\u2010medical\u2010product\u2010development\u2010support\u2010labeling\u2010claims."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27476"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S178344"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30037-1"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25529"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26152"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21142"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26910"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21016"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21053"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01593882"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/14653125221076142"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002971"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-200484"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.02.025"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:20:52Z","timestamp":1764228052000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/mus.70013"],"URL":"https:\/\/doi.org\/10.1002\/mus.70013","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}