{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T17:14:59Z","timestamp":1762794899780,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Approaches to optimize physical activity in youth with spinal muscular atrophy (SMA) are rapidly evolving. The primary objective of this study was to assess the feasibility of a fit\u2010for\u2010purpose home\u2010based exergaming intervention in children and youth with SMA and peer controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a 4\u2010week study at two Canadian sites to assess the feasibility of Tales from the Magic Keep, a home\u2010based exergame specifically developed for youth with neuromuscular disorders that targets upper limb and trunk movements. Participants were asked to play the exergame for at least 20\u2009min per session, 4 times a week for 4\u2009weeks, and wear an accelerometer\u2010based wearable device. Adherence, acceptability, and usability evaluations informed feasibility determinations. Adherence was quantified by gameplay frequency and duration. Acceptability and usability were assessed using study\u2010specific questionnaires and the system usability scale (\n                      <jats:styled-content style=\"fixed-case\">SUS<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 12 participants, 8 of whom completed the study: 4 SMA (3 Type\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      , 1 Type\n                      <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                      ) and 4 controls. Among those 8, adherence was high, with an average of 4.5 and 3.5 sessions per week for the\n                      <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>\n                      and control groups respectively, and they found gameplay to be acceptable and enjoyable. The median score on the\n                      <jats:styled-content style=\"fixed-case\">SUS<\/jats:styled-content>\n                      was 68\/100. The wearable device was generally well accepted; participants reported it as comfortable to wear and not interfering with daily activities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The exergame was feasible and acceptable in two thirds of participants. Iterative feedback obtained during this study led to subsequent updates to the game interface to optimize gameplay.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70032","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:10:49Z","timestamp":1758708649000},"page":"1259-1264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of a Home\u2010Based Exergaming Intervention for Youth With Spinal Muscular Atrophy"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6923-970X","authenticated-orcid":false,"given":"Ihsane","family":"Iraqi","sequence":"first","affiliation":[{"name":"Department of Neuroscience McGill University  Montreal Quebec Canada"},{"name":"Centre for Outcomes Research and Evaluation McGill University Health Centre Research Institute  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Ng","sequence":"additional","affiliation":[{"name":"Centre for Outcomes Research and Evaluation McGill University Health Centre Research Institute  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Chen","sequence":"additional","affiliation":[{"name":"Roche Information Solutions, F. Hoffmann\u2010La Roche AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niamh","family":"Cushen","sequence":"additional","affiliation":[{"name":"BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9695-572X","authenticated-orcid":false,"given":"Juergen","family":"Gottowik","sequence":"additional","affiliation":[{"name":"Roche Pharmaceutical Research and Early Development, F. Hoffmann\u2010La Roche AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Herzig","sequence":"additional","affiliation":[{"name":"Roche Pharmaceutical Research and Early Development, F. Hoffmann\u2010La Roche AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaainthabie","family":"Karthigesu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Levac","sequence":"additional","affiliation":[{"name":"School of Rehabilitation University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital of Eastern Ontario  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean K.","family":"Mah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slawomir","family":"Opalka","sequence":"additional","affiliation":[{"name":"Transition Technologies PSC  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Potter","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Selby","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Sheriko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen","family":"Smith","sequence":"additional","affiliation":[{"name":"Canadian Organization for Rare Disorders  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Turgeon\u2010Desilets","sequence":"additional","affiliation":[{"name":"School of Physical and Occupational Therapy McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelina","family":"Woof","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-0108","authenticated-orcid":false,"given":"Maryam","family":"Oskoui","sequence":"additional","affiliation":[{"name":"Centre for Outcomes Research and Evaluation McGill University Health Centre Research Institute  Montreal Quebec Canada"},{"name":"Departments of Pediatrics and Neurology &amp; Neurosurgery McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742\u20106596\/705\/1\/012060"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2010.09.0171"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-404705-1.00006-6"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010017\u20100853\u2010y"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/jnd\u2010210743"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.94.15_supplement.530"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170472"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25430"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811420294"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2011.00037"},{"volume-title":"Usability Evaluation in Industry","year":"1996","author":"Brooke J.","key":"e_1_2_12_12_1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2196\/37290"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1131573"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13446"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2016.09.004"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmedt.2023.1217797"}],"container-title":["Muscle &amp; 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