{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:03:34Z","timestamp":1791407014701,"version":"4.3.3"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018748","name":"Argenx","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aim<\/jats:title>\n                    <jats:p>Survival outcomes have been inadequately studied among people with myasthenia gravis (MG) in the United States (US). We examined the impact of MG and comorbid conditions on longevity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a longitudinal study using Medicare claims data (2006\u20132019). Incident\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      cohort was identified based on the following criteria: age\u2009\u2265\u200965\u2009years; \u2265\u20091\u2009month of fee\u2010for\u2010service Parts A and B coverage; no health maintenance organization coverage; initial and subsequent\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      claims within 2010\u20132011 separated by \u2265\u200928\u2009days. A non\u2010\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      cohort of five times the number of the\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      group was selected, matching for age, sex, region, and Medicare coverage duration. Overall and cause\u2010specific mortality were compared between cohorts in the subsequent 8\u201310\u2009Years using Kaplan\u2013Meier plots and Cox proportional hazard models, adjusted for the Charlson Comorbidity Index (\n                      <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cohorts of 6024 incident\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      and 30,083 control beneficiaries were Included. The mortality rate was higher in the\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      cohort compared to controls (66.8 vs. 57.1 per 1000\u2010person\u2010year,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). After adjusting for time\u2010varying\n                      <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\n                      , no significant difference in survival was observed between two cohorts (adjusted hazard ratio 1.09 [0.87\u20131.36],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.47). Sixteen percent of deaths in the\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      cohort were attributed to\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      . Compared to the non\u2010\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      cohort, mortality rates (per 1000\u2010person\u2010year) specific to infections were higher among the\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      cohort (2.0 vs. 1.2) while malignancies and dementia\u2010specific mortality rates were lower (10.3 vs. 12.5 and 4.7 vs. 7.2), all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Long\u2010term mortality is increased in elderly\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      patients compared to non\u2010\n                      <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>\n                      counterparts, driven by their higher comorbidity burden.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70045","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T09:21:20Z","timestamp":1760692880000},"page":"41-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Survival Outcomes of Medicare\u2010Covered Elderly\n                    <scp>US<\/scp>\n                    Population With Myasthenia Gravis"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4248-8927","authenticated-orcid":false,"given":"Yuebing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Cleveland Clinic  Cleveland Ohio 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Hehir","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikjae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-46"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2020.08.355"},{"issue":"10","key":"e_1_2_10_4_1","first-page":"919","article-title":"Epidemiology of Myasthenia Gravis in Denmark, Finland and Sweden: A Population\u2010Based Observational Study","volume":"95","author":"Vissing 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