{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:43:35Z","timestamp":1783100615121,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Patients with non\u2010length\u2010dependent neuropathy (NLDN) exhibit reduced sensory nerve action potential (SNAP) amplitudes in both lower and upper limbs. This study aimed to determine a threshold for the sural\/radial amplitude ratio (SRAR) suggestive of NLDN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case\u2013control study involved 60 patients with definite NLDN (sensory neuronopathy [SNN] or chronic inflammatory demyelinating polyradiculoneuropathy [CIDP]) and 30 patients with length\u2010dependent neuropathy (LDN). The diagnostic performance of SRAR was evaluated using the area under the curve (AUC) of the modeled receiver operating characteristic (ROC) curve. The presence of a length\u2010dependent electrodiagnostic (EDX) pattern, defined as a sural SNAP amplitude lower than the radial one, was evaluated in each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SRAR could be calculated in 90\/164 (54.9%) of patients screened. Among patients with NLDN, the median SRAR was 0.74 (IQR 0.50\u20131.00) compared to 0.17 (IQR 0.12\u20130.23) in patients with LDN. The ROC curve analysis for NLDN versus LDN yielded an AUC of 0.94 (95% CI, 0.883\u20130.979). The SRAR threshold of 0.33 provided a sensitivity of 84.4% (95% CI, 77.8%\u201390.9%), specificity of 86.9% (95% CI, 79.7%\u201394%). The length\u2010dependent EDX pattern was observed in 100% (30\/30) of LDN patients and 63% (38\/60) of NLDN patients. Among these 38 patients with NLDN, SRAR exceeded 0.33 in 78.9% (30\/38).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>SRAR appears to be useful in the electrophysiological evaluation of neuropathies. In addition to usual diagnostic criteria, an SRAR &gt;\u20090.33 may strongly suggest NLDN such as SNN or CIDP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70046","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:36:11Z","timestamp":1759995371000},"page":"34-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sural\/Radial Amplitude Ratio: A Useful Tool to Diagnose Non\u2010Length\u2010Dependent Neuropathy"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1563-9432","authenticated-orcid":false,"given":"Antoine","family":"Pegat","sequence":"first","affiliation":[{"name":"H\u00f4pital Neurologique Pierre Wertheimer Service d\u2019ENMG et de Pathologies Neuromusculaires, Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires PACA\u2010R\u00e9union\u2010Rh\u00f4ne Alpes, Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Gavoille","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon Service de Neurologie, Scl\u00e9rose en Plaques, Pathologies de la My\u00e9line et Neuro\u2010Inflammation  Bron France"},{"name":"Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive UMR 5558 Universit\u00e9 Lyon 1, CNRS  Villeurbanne France"},{"name":"Service de Biostatistique\u2010Bioinformatique Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-7395","authenticated-orcid":false,"given":"Florent","family":"Cluse","sequence":"additional","affiliation":[{"name":"H\u00f4pital Neurologique Pierre Wertheimer Service d\u2019ENMG et de Pathologies Neuromusculaires, Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires PACA\u2010R\u00e9union\u2010Rh\u00f4ne Alpes, Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Moussy","sequence":"additional","affiliation":[{"name":"H\u00f4pital Neurologique Pierre Wertheimer Service d\u2019ENMG et de Pathologies Neuromusculaires, Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires PACA\u2010R\u00e9union\u2010Rh\u00f4ne Alpes, Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Petiot","sequence":"additional","affiliation":[{"name":"H\u00f4pital Neurologique Pierre Wertheimer Service d\u2019ENMG et de Pathologies Neuromusculaires, Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires PACA\u2010R\u00e9union\u2010Rh\u00f4ne Alpes, Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Camdessanch\u00e9","sequence":"additional","affiliation":[{"name":"Service de Neurologie Centre Hospitalier Universitaire  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Bouhour","sequence":"additional","affiliation":[{"name":"H\u00f4pital Neurologique Pierre Wertheimer Service d\u2019ENMG et de Pathologies Neuromusculaires, Centre de R\u00e9f\u00e9rence des Maladies Neuromusculaires PACA\u2010R\u00e9union\u2010Rh\u00f4ne Alpes, Hospices Civils de Lyon  Bron 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