{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T09:24:44Z","timestamp":1770542684644,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Local corticosteroid injection (LCI) improves symptoms in the injected hand of carpal tunnel syndrome (CTS). Whether it affects the non\u2010injected hand is unknown. This study assesses the effect of unilateral LCI on the non\u2010injected hand in mild to moderate bilateral CTS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty patients with bilateral CTS were recruited from December 2021 to August 2024 and received a unilateral injection of 1\u2009mL (40\u2009mg) depo\u2010methylprednisolone with 0.5\u2009mL (10\u2009mg) lidocaine in the more severely affected or dominant hand if symptoms were comparable. The primary outcome was the change in Symptom Severity Scale (SSS) score of the non\u2010injected hand at 1 and 3\u2009months. Secondary outcomes were the comparison of response rates and the change in the median nerve electrophysiology at 3\u2009months in both hands. A significant response was defined as \u2265\u20090.8 reduction in SSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age of patients was 45 (range 20\u201381) years. Seven patients were lost to follow\u2010up at 1\u2009month and 15 at 3\u2009months. Mean SSS change was significantly greater in the injected than in the non\u2010injected hands at 1\u2009month (\u22121.25\u2009\u00b1\u20090.64 vs. \u22120.89\u2009\u00b1\u20090.67;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and 3\u2009months (\u22121.23\u2009\u00b1\u20090.72 vs. \u22120.77\u2009\u00b1\u20090.64;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Taking patients lost to follow\u2010up as treatment failures, response rates at 3\u2009months were 65% in injected hands and 57% in non\u2010injected hands (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.45). Median nerve conduction improved bilaterally at 3\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Unilateral\n                      <jats:styled-content style=\"fixed-case\">LCI<\/jats:styled-content>\n                      in bilateral mild to moderate\n                      <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>\n                      results in significant symptomatic improvement in the contralateral hand, underscoring the need to routinely assess the non\u2010injected hand in treatment assessment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70082","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T08:40:29Z","timestamp":1763800829000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Local Corticosteroid Injection in the Non\u2010Injected Hand Following Unilateral Injection in Patients With Bilateral Carpal Tunnel Syndrome: A Prospective Cohort Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4113-9186","authenticated-orcid":false,"given":"Mritunjai","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9489-4905","authenticated-orcid":false,"given":"Niket","family":"Yende","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagbir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajni","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology All India Institute of Medical Sciences  Rishikesh India"},{"name":"Tehri Hydro Development Corporation Limited  Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2311-8891","authenticated-orcid":false,"given":"Ashutosh","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  Gorakhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-2532","authenticated-orcid":false,"given":"Niraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  Bibinagar India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00713854"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pjnns.2017.09.009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-5-201309030-00004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0002-7"},{"issue":"2","key":"e_1_2_11_6_1","article-title":"Local Corticosteroid Injection Versus Placebo for Carpal Tunnel Syndrome","volume":"2","author":"Ashworth N. L.","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01412313"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200107000-00004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-014-9719-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880161219"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22208"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00704-0"},{"issue":"11","key":"e_1_2_11_13_1","first-page":"1585","article-title":"A Self\u2010Administered Questionnaire for the Assessment of Severity of Symptoms and Functional Status in Carpal Tunnel Syndrome","volume":"75","author":"Levine D. W.","year":"1993","journal-title":"Journal of Bone and Joint Surgery. 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