{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T14:05:54Z","timestamp":1771164354926,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Small fiber neuropathy (SFN) is a common neurological diagnosis with a multitude of symptoms, including dysautonomia symptoms (e.g., orthostatic dizziness) as well as sensory disturbances, such as a tingling sensation or burning pain. The disease can be due to metabolic, autoimmune, or hereditary factors, and treatment plans stem from SFN etiology. Diabetes, autoimmune disease, infection, vitamin deficiencies, post\u2010vaccination syndromes can all cause SFN. Needle electromyography and nerve conduction studies can be performed to exclude other neuromuscular conditions by ruling out large fiber neuropathies. The gold standard of diagnosis for SFN remains an abnormal skin biopsy. For non\u2010idiopathic cases, treatment of underlying causes, including metabolic, nutritional, infectious, autoimmune, or toxin\u2010related, is critical for symptom improvement. Most treatment options for idiopathic SFN are geared toward symptom management for neuropathic pain and paresthesia and include antiepileptics, antidepressants, and topical ointments. First\u2010line medications include amitriptyline, nortriptyline, gabapentin, and pregabalin. Second\u2010line treatments can include serotonin\u2010norepinephrine reuptake inhibitors and selective serotonin reuptake inhibitors such as duloxetine and venlafaxine, as well as lidocaine patches and capsaicin.<\/jats:p>","DOI":"10.1002\/mus.70086","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:31:07Z","timestamp":1765355467000},"page":"380-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of Small Fiber Neuropathy: A Clinical Perspective"],"prefix":"10.1002","volume":"73","author":[{"given":"Jordan","family":"Yaukey","sequence":"first","affiliation":[{"name":"Department of Neurology Pennsylvania State Milton S. Hershey Hospital  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Neurology Pennsylvania State Milton S. 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