{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T14:05:55Z","timestamp":1771164355050,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>With implementation of newborn screening (NBS) for Duchenne muscular dystrophy (DMD), creatine kinase\u2010muscle (CK) values will be reported on newborns. Maternal, labor, delivery, and newborn factors may elevate CK levels, raising concern for DMD. Predictive modeling could aid hyperCKemia interpretation while awaiting diagnostic confirmation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010center, prospective cohort study, parents of 8365 newborns were offered DMD\u2010NBS. Electronic health records provided data on candidate predictors of hyperCKemia defined by values &gt;\u200997th or 99th percentiles, or 2000\u2009ng\/mL in babies with normal\n                      <jats:italic>DMD<\/jats:italic>\n                      sequences. Exposures included maternal, newborn and perinatal factors. Associations between predictors and hyperCKemia were evaluated using univariate logistic regression. A multivariable prediction model for the 97th percentile was derived using backward stepwise logistic regression and externally validated in a cohort of 2672 newborns.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HyperCKemia &gt;\u200997th percentile was the main outcome. Univariate analyses revealed associations between hyperCKemia and maternal ethnicity, primiparity, labor and delivery complications, oxytocin induction or augmentation, duration of ruptured membranes, forceps or vacuum\u2010assisted delivery, neonatal resuscitation, sex, gestational age, birth weight, and Apgar scores. Lower odds of hyperCKemia were associated with later hour\u2010of\u2010life at sample collection and birth by cesarean section. The final model included parity, shoulder dystocia, forceps or vacuum\u2010assisted delivery, gestational age, neonatal resuscitation, Apgar score (1\u2009min), and time of sample collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Elevated CK levels may be used for DMD\u2010NBS. Multiple perinatal factors are associated with transient non\u2010DMD hyperCKemia. Our model considers the potential combined impact of such factors and generates a non\u2010disease likelihood for preliminary hyperCKemia interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70089","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:22:17Z","timestamp":1767788537000},"page":"459-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interpreting Neonatal\n                    <scp>hyperCKemia<\/scp>\n                    Identified Through Duchenne Muscular Dystrophy Newborn Screening: A Predictive Model Based on Maternal, Labor, Delivery and Newborn Factors"],"prefix":"10.1002","volume":"73","author":[{"given":"Elisa N.","family":"Falk","sequence":"first","affiliation":[{"name":"Department of Neurology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Division of Newborn Medicine, Department of Pediatrics Brigham &amp; Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Chrzanowski","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Division of Newborn Medicine, Department of Pediatrics Brigham &amp; Women's Hospital  Boston Massachusetts USA"},{"name":"Division of Neuromuscular Medicine, Department of Neurology Brigham &amp; Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Coyne","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Brigham &amp; Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Sheldon","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Brigham &amp; Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Cherkerzian","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Brigham &amp; Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B.","family":"Parad","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Brigham &amp; Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27533"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.32000"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijns8040050"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.1782"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijns7040077"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2022.11.024"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2023.101009"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.5.362"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880090103"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(88)90414\u2010X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/gte.1998.2.55"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23528"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.301"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519\u2010017\u20100036\u20103"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.05.244"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(89)92170\u20103"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.17712\/nsj.2022.4.20220051"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2023.110614"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.10.009"},{"key":"e_1_2_11_21_1","first-page":"189","article-title":"Correlation of Creatine Phosphokinase Blood Level With Prenatal Fetal Heart Rate as a Prognostic Factor in Tissue Hypoxia","volume":"60","author":"Jim\u00e9nez Solis G.","year":"1992","journal-title":"Ginecolog\u00eda y Obstetricia de M\u00e9xico"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010015\u20100188\u20105"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301\u20102115(01)00417\u20101"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651\u20102227.1981.tb05779.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25390"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651\u20102227.2007.00361.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102431\u201013\u201092"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161\u20101165.1000227"},{"key":"e_1_2_11_29_1","volume-title":"Multiple Regression in Practice (Quantitative Applications in the Social Sciences)","author":"Berry W. 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