{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:41:04Z","timestamp":1790811664566,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) syndrome is a rare paraneoplastic syndrome associated with significant neurologic morbidity. Better understanding of the manifestations of this disease is crucial to early diagnosis and improvement of prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed medical record data of adult patients diagnosed with POEMS syndrome between 2007 and December 2023 fulfilling the 2014 International Myeloma Working Group criteria for POEMS syndrome in a single tertiary care Hospital in Brazil. Clinical, laboratory and electrophysiological data were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010three patients were included, with median time from symptom onset to diagnosis of 13 (11\u201335) months, and 30% of patients were nonambulatory at the diagnosis. Neuropathy was present in 100% of patients, and early proximal muscle weakness was present in 57%. Nerve conductions studies (NCS) disclosed demyelinating polyneuropathy with axonal damage in 96% and conduction block in 33%. Serum monoclonal paraprotein heavy chain was IgG subtype in 73% and lambda light chain in 91%. Castleman disease was diagnosed in 6% of patients. Organomegaly, bone lesions and endocrinological profiles were similar to previously reported cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Patients in our cohort had similar clinical profiles to previously reported data. However, unlike other large cohorts, our study showed a high proportion of IgG class paraprotein, non\u2010length\u2010dependent findings and conduction block on electrophysiology, and a lower number of cases associated with Castleman's disease. Our findings highlight the importance of pursuing a POEMS syndrome diagnosis even in the presence of atypical electrophysiological features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70114","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:10:39Z","timestamp":1766049039000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neurological Peculiarities of\n                    <scp>POEMS<\/scp>\n                    Syndrome: Experience From a Brazilian University Center"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2482-9011","authenticated-orcid":false,"given":"Renan Fabri","family":"Rosenstein","sequence":"first","affiliation":[{"name":"Divis\u00e3o de Cl\u00ednica Neurol\u00f3gica Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo\u2010S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Pedro","family":"Soares Baima","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Cl\u00ednica Neurol\u00f3gica Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo\u2010S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Unidade Do Sistema Nervoso Hospital Universit\u00e1rio da Universidade Federal Do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thales Dalessandro","family":"Meneguin Pereira","sequence":"additional","affiliation":[{"name":"Instituto de C\u00e2ncer do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo\u2010S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Divis\u00e3o de Hematologia Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo\u2010S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gracia Aparecida","family":"Martinez","sequence":"additional","affiliation":[{"name":"Instituto de C\u00e2ncer do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo\u2010S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Divis\u00e3o de Hematologia Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo\u2010S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Otto","family":"Heise","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Cl\u00ednica Neurol\u00f3gica Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo\u2010S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina Maria Martins","family":"Lino","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Cl\u00ednica Neurol\u00f3gica Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo\u2010S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008062"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102002\u201007\u20102299"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.6.71"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009940"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.07.124"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010010\u20101149\u20100"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90350-6"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004\u2010282X2007000300030"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034\u201098872009000500013"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)70442\u20105"},{"key":"e_1_2_13_12_1","first-page":"44","article-title":"Helping Patients Who Drink Too Much: An Evidence\u2010Based Guide for Primary Care Physicians","volume":"80","author":"Willenbring M. 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