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This 12\u2010month study investigates qMRI responsiveness across disease stages and identifies early\u2010stage damage markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 137 DMD patients (9.1\u2009\u00b1\u20091.8\u2009years) and 32 controls (9.5\u2009\u00b1\u20092.0\u2009years) were prospectively enrolled and underwent 3\u2009T MRI (T1 mapping, 3\u2010point Dixon) assessing fat fraction (FF) and T1 in gluteal muscle groups (flexors, extensors, adductors, and abductors). Patients underwent North Star Ambulatory Assessment (NSAA) and timed functional tests and were classified by baseline NSAA scores into mild (76\u2013100), moderate (51\u201375), and severe (0\u201350) groups. Standardized response mean (SRM) was used as a measure of disease progression responsiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over 12\u2009months, the severe group showed greater\n                      <jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content>\n                      changes (except adductors) than mild\/moderate groups, while\n                      <jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content>\n                      changes of the adductors were only higher than the mild group. The moderate group had greater\n                      <jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content>\n                      changes than the mild group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                      <jats:styled-content style=\"fixed-case\">qMRI<\/jats:styled-content>\n                      responsiveness to disease progression varied by disease stage, with\n                      <jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content>\n                      of the abductors in the mild functional stable\/decline group (\n                      <jats:styled-content style=\"fixed-case\">SRM<\/jats:styled-content>\n                      \u2009=\u20091.016\/1.445) and adductors in moderate\/severe groups (\n                      <jats:styled-content style=\"fixed-case\">SRM<\/jats:styled-content>\n                      \u2009=\u20091.606\/1.633) showing the highest responsiveness.\n                      <jats:styled-content style=\"fixed-case\">SRM<\/jats:styled-content>\n                      for function scales remained below 0.8 in all\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      subgroups.\n                      <jats:styled-content style=\"fixed-case\">qMRI<\/jats:styled-content>\n                      biomarkers demonstrated potential for identifying early\u2010stage patients with or without functional decline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>qMRI of the gluteal muscle group demonstrates higher responsiveness to DMD progression than function scales, with sensitivity varying by disease stage. qMRI biomarkers appear to be useful for assessing subclinical progression detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70115","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:35:07Z","timestamp":1766399707000},"page":"434-444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Magnetic Resonance Imaging of Gluteal Muscle Groups Detects Stage\u2010Specific Progression and Early\u2010Stage Damage in Duchenne Muscular Dystrophy: A 12\u2010Month Longitudinal Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1198-0732","authenticated-orcid":false,"given":"Yu","family":"Song","sequence":"first","affiliation":[{"name":"Department of Radiology, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education West China Second University Hospital, Sichuan University  Chengdu People's Republic of 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