{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T14:05:56Z","timestamp":1771164356896,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["grant\u20192013\/07559\u20103\u2019"],"award-info":[{"award-number":["grant\u20192013\/07559\u20103\u2019"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Pain\u2010related evoked potentials with concentric electrodes (PrEP\u2010CE) provide a method for screening for small fiber neuropathy, which is usually the first manifestation of hereditary transthyretin amyloid polyneuropathy (ATTR v\u2010PN). Despite that, this technique has not yet been fully explored in this condition. The current study aimed to compare PrEP\u2010CE responses among patients with ATTRv\u2010PN, presymptomatic carriers of TTR mutations, and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 17 patients with ATTRv\u2010PN, 12 presymptomatic TTR mutation carriers (pre\u2010ATTRv\u2010PN), and 13 healthy controls. PrEP\u2010CE were obtained by separately stimulating the hands and feet. We analyzed the latencies of negative (N1) and positive (P1) peaks and peak\u2010to\u2010peak amplitudes between groups using nonparametric tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median ages were 45\u2009years for both ATTRv\u2010PN and pre\u2010ATTRv\u2010PN groups, and 32\u2009years for controls. In the arms, N1 and P1 latencies were significantly longer in the ATTRv\u2010PN group compared to controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In the legs, P1 latency was significantly longer in the ATTRv\u2010PN (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and the pre\u2010ATTRv\u2010PN (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) groups vs. controls. PrEP\u2010CE amplitudes were reduced in both the ATTRv\u2010PN (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) and the pre\u2010ATTRv\u2010PN (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021) compared to the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>PrEP\u2010CE facilitates recognition of ATTRv\u2010PN, with lower limb P1 latency and amplitude indicating small fiber involvement. It is a rapid, well\u2010tolerated technique that may support the assessment of small\u2010fiber impairment in ATTRv\u2010PN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70132","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T10:07:19Z","timestamp":1767434839000},"page":"452-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain\u2010Related Evoked Potentials in Hereditary Transthyretin Amyloidosis With Polyneuropathy"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6560-0061","authenticated-orcid":false,"given":"Renan Fl\u00e1vio de Fran\u00e7a","family":"Nunes","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Medical Sciences University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paula Carvalho","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medical Sciences University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Rolim Muro","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medical Sciences University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Junqueira Ribeiro de","family":"Rezende","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medical Sciences University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Marcondes C.","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medical Sciences University of Campinas  Campinas 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