{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T13:50:36Z","timestamp":1775224236797,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Guidelines for the management of chronic inflammatory demyelinating polyneuropathy (CIDP) recommend corticosteroids, intravenous immunoglobulin (IVIg), or plasma exchange for first\u2010line therapies and subcutaneous immunoglobulin (SCIg) as a maintenance option. Literature on clinical experience with SCIg in CIDP maintenance therapy is limited. This study outlines practical approaches to SCIg transition and management optimization, considering the varying dosing recommendations in prescribing information and clinical guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, multicenter study analyzed anonymized patient medical records from eight US centers. Patients with CIDP who transitioned to SCIg were included, and clinical practices regarding SCIg therapy management were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>These 20 cases presented practical and clinical considerations for successful SCIg transition and maintenance. Switching decisions were guided by patient\u2010physician assessment of treatment goals, benefits, and risks. The most common reason for switching (70%) was preference for site of care. Eight patients (40%) transitioned to a dose equivalent to their baseline IVIg dose. Overall, 12\/19 patients (63%) remained stable following transition. Relapse\u2010free rates were higher in patients who transitioned to a higher (67%) or lower (75%) than baseline dose versus those who received an equivalent dose (50%). All relapsed patients restabilized after increasing their SCIg dose. The final mean (SD) SCIg dose was 0.32 (0.15) g\/kg\/week. SCIg was well tolerated; 11 patients (55%) reported better tolerance versus IVIg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These patient cases provide practical guidance for SCIg therapy in CIDP maintenance, emphasizing individualized dosing strategies, ongoing monitoring, and patient\u2010centered engagement. The findings help inform clinical decision\u2010making to optimize long\u2010term therapeutic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70151","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:15:08Z","timestamp":1769519708000},"page":"765-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Practical Approach to Managing\n                    <scp>SCIg<\/scp>\n                    Treatment in Patients With Chronic Inflammatory Demyelinating Polyneuropathy"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0724-0210","authenticated-orcid":false,"given":"Tuan","family":"Vu","sequence":"first","affiliation":[{"name":"GBS\/CIDP Center of Excellence University of South Florida Morsani College of Medicine  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Guerra","sequence":"additional","affiliation":[{"name":"GBS\/CIDP Center of Excellence University of South Florida Morsani College of Medicine  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niraja","family":"Suresh","sequence":"additional","affiliation":[{"name":"Lakeland Regional Medical Center  Lakeland Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Khella","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Morrell","sequence":"additional","affiliation":[{"name":"PromptCare  New Providence New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pulley","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Florida College of Medicine  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khema","family":"Sharma","sequence":"additional","affiliation":[{"name":"Neurology Department Miller School of Medicine, University of Miami  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tulio","family":"Bertorini","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Sciences Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivedita","family":"Jerath","sequence":"additional","affiliation":[{"name":"AdventHealth Neuroscience Institute  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1097-7715","authenticated-orcid":false,"given":"Amanda","family":"Peltier","sequence":"additional","affiliation":[{"name":"Neuromuscular Division Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12455"},{"key":"e_1_2_14_3_1","unstructured":"U.S. Food & Drug Administration Immune Globulin Intravenous (Human) (IVIG) 10% Liquid Privigen Prescribing Information 2022."},{"key":"e_1_2_14_4_1","unstructured":"U.S. Food & Drug Administration Immune Globulin Subcutaneous (Human) (IGSC) 20% Liquid Hizentra Prescribing Information 2023."},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000590"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND\u2010221615"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505320"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101331.2009.02930.x"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008742"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(17)30378\u20102"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab422"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(07)70329\u20100"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285614563056"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116497"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2019.912"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369\u20107625.2011.00757.x"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2018.363"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T13:02:49Z","timestamp":1775221369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/mus.70151"],"URL":"https:\/\/doi.org\/10.1002\/mus.70151","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"2024-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}