{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:01:45Z","timestamp":1788483705217,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction\/Aims<\/jats:title>\n The value of electrodiagnostic subtyping of Guillain\u2013Barr\u00e9 syndrome (GBS) is still debated. This study aimed to determine the diagnostic yield, timing, and changes of the electrodiagnostic subtyping in patients with GBS in serial nerve conduction studies (NCS).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Data were extracted from the International GBS Outcome Study (IGOS) database. Serial NCS were available for 469 patients. For the serial NCS analysis, the intervals between the first and second study were defined as \u2265\u20097 and \u2264\u200942\u2009days after onset of weakness. All NCS were classified according to the electrodiagnostic criteria sets of Hadden et\u00a0al. and Rajabally et\u00a0al.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In NCS conducted within 3\u2009days of onset of weakness, an axonal or demyelinating subtype could be demonstrated in 58.4% (Hadden) and 52.1% (Rajabally). NCS performed at a later timepoint demonstrated a similar yield of axonal and demyelinating subtypes. In patients with motor\u2010sensory and motor GBS, the electrodiagnostic subtype changed on serial NCS in 37.8% (Hadden) and 44.7% (Rajabally). As the subtypes changed in multiple and opposite directions, the total proportion of axonal and demyelinating subtypes remained stable across time points. In patients with motor GBS, both axonal and demyelinating subtypes were found.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n This study demonstrates the highly dynamic disease course of GBS. The role of NCS remains to support the clinical diagnosis of GBS and should be performed as quickly as possible after onset of weakness. If these early NCS are non\u2010diagnostic, repeating the study should be considered. Electrodiagnostic subtyping offers no additional value.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mus.70152","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T06:54:03Z","timestamp":1770620043000},"page":"832-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dynamics of Nerve Conduction Studies in Patients With Guillain\u2013Barr\u00e9 Syndrome"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4279-4657","authenticated-orcid":false,"given":"Samuel","family":"Arends","sequence":"first","affiliation":[{"name":"Department of Neurology\/Clinical Neurophysiology HagaZiekenhuis The Hague the Netherlands"},{"name":"Department of Neurology Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"de Koning","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Drenthen","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahova","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Y. K.","family":"van den Bergh","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital St\u2010Luc Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-0256","authenticated-orcid":false,"given":"Robert M.","family":"Hadden","sequence":"additional","affiliation":[{"name":"Department of Neurology King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nortina","family":"Shahrizaila","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo C.","family":"Reisin","sequence":"additional","affiliation":[{"name":"Department of Neurology Fundacion Para la Lucha Contra Las Enfermedades Neurologicas de la Infancia Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4716-8578","authenticated-orcid":false,"given":"Satoshi","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Neurology Chiba University Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senda","family":"Ajroud\u2010Driss","sequence":"additional","affiliation":[{"name":"Department of Neurology Northwestern University Feinberg Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Antonini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mental Health and Sensory Organs (NESMOS) Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Balducci","sequence":"additional","affiliation":[{"name":"Department of Neurology San Gerardo Hospital Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio A.","family":"Barroso","sequence":"additional","affiliation":[{"name":"Department of Neurology Fundacion Para la Lucha Contra Las Enfermedades Neurologicas de la Infancia Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-8331","authenticated-orcid":false,"given":"Thomas H.","family":"Brannagan","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Buermann","sequence":"additional","affiliation":[{"name":"Department of Neurology Saarland University Hospital Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Casasnovas","sequence":"additional","affiliation":[{"name":"Department of Neurology San Gerardo Hospital Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Cavaletti","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario de Bellvitge Servicio de Neurologica Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Chao","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Dillmann","sequence":"additional","affiliation":[{"name":"Department of Neurology Saarland University Hospital Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen M.","family":"Dimachkie","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Kansas Medical Center Kansas Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Galassi","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Modena Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Guti\u00e9rrez\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Infanta Sof\u00eda Madrid Spain"},{"name":"Department of Medicine, Faculty of Biomedical and Health Sciences Universidad Europea de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Harbo","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Tsang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Neurology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-944X","authenticated-orcid":false,"given":"Badrul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurophysiology BRB Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Katzberg","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Kiers","sequence":"additional","affiliation":[{"name":"Department of Neurology The Royal Melbourne Hospital City Campus Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Mataluni","sequence":"additional","affiliation":[{"name":"Dysimmune Neuropathies Unit, Department of Systems Medicine University of Rome Tor Vergata Rome 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