{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:16:19Z","timestamp":1773098179753,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction\/Aims<\/jats:title>\n Juvenile myasthenia gravis (JMG) patients report symptomatic improvement following thymectomy; however, there is a lack of published literature on biomarkers for interval improvement. This study aimed to investigate the utility of single\u2010fiber electromyography to quantify changes post\u2010thymectomy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This was a retrospective medical record review of JMG patients who underwent thymectomy at Children's Healthcare of Atlanta between 2014 and 2024. Pre\u2010 and post\u2010thymectomy orbicularis oculi jitter values and Myasthenia Gravis Activities of Daily Living (MG\u2010ADL) scores were recorded. A two\u2010sided paired t\u2010test was used to compare results pre\u2010 and post\u2010thymectomy and Pearson's correlations were calculated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twelve JMG patients (6 female) with a mean age at diagnosis of 12.9\u2009\u00b1\u20094.5 (range 1.6\u201317.1) years, positive acetylcholine receptor antibodies, and normal thymus imaging underwent thoracoscopic thymectomy at 15.2\u2009\u00b1\u20093.3 (range 7.4\u201318.2) years. Post\u2010thymectomy, there was a statistically significant decrease in mean jitter (interval 7.3\u2009\u00b1\u20097.4\u2009months, mean difference \u221233.2\u2009\u00b1\u200932.6\u2009\u03bcs,\n p<\/jats:italic>\n \u2009=\u20090.04,\n n<\/jats:italic>\n \u2009=\u20097) and MG\u2010ADL scores (interval 2.5\u2009\u00b1\u20092.1\u2009years, mean difference \u22122.2\u2009\u00b1\u20092.5,\n p<\/jats:italic>\n \u2009=\u20090.02,\n n<\/jats:italic>\n \u2009=\u200911). There were no significant correlations between timing of thymectomy after diagnosis and the change in mean jitter (\n r<\/jats:italic>\n \u2009=\u20090.11,\n p<\/jats:italic>\n \u2009=\u20090.8,\n n<\/jats:italic>\n \u2009=\u20097) and MG\u2010ADL (\n r<\/jats:italic>\n \u2009=\u2009\u22120.19,\n p<\/jats:italic>\n \u2009=\u20090.58,\n n<\/jats:italic>\n \u2009=\u200911). No major post\u2010surgical complications were observed.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Thymectomy is well\u2010tolerated and leads to both objective and subjective improvement in JMG patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mus.70170","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T14:05:42Z","timestamp":1770127542000},"page":"650-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improved Neuromuscular Transmission Following Thymectomy in Juvenile Myasthenia Gravis: A Case Series"],"prefix":"10.1002","volume":"73","author":[{"given":"Natalie","family":"Givens","sequence":"first","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soham","family":"Verma","sequence":"additional","affiliation":[{"name":"Johns Creek High School Johns Creek Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Moghadam","sequence":"additional","affiliation":[{"name":"Philadelphia College of Osteopathic Medicine \u2013 South Georgia Moultrie Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Meisel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Hoeting","sequence":"additional","affiliation":[{"name":"Department of Statistics Colorado State University Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1992-4556","authenticated-orcid":false,"given":"Sumit","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neurology Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJNO\u20102024\u2010001000"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00743"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011124"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00383\u2010017\u20104086\u20103"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26319"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27476"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.52.7.1487"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_2_10_11_1","unstructured":"Team RC \u201cR: A Language and Environment for Statistical Computing \u201d 2024 https:\/\/www.R\u2010project.org."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100404.2005.00424.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.12.053"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00604"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602489"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2016.04.002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.12.045"}],"container-title":["Muscle & Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:47:21Z","timestamp":1773060441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/mus.70170"],"URL":"https:\/\/doi.org\/10.1002\/mus.70170","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]},"assertion":[{"value":"2025-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}