{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:19:11Z","timestamp":1791854351244,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>The association between low forced vital capacity (FVC) and cognitive impairment in ALS is ambiguous; it could be due to respiratory dysfunction and\/or poor effort from cognitive deficits. We used the objective, non\u2010volitional phrenic nerve motor response amplitude (PAmp) to clarify how cognitive status affects the relationship between diaphragmatic strength and FVC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 73 patients with ALS followed in our clinic. FVC and PAmp were measured, and cognitive status was assessed with the Edinburgh Cognitive and Behavioral ALS Screen (ECAS). Regression models tested for associations between FVC and distinct ECAS domains and whether these domains influenced the PAmp\u2010FVC relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PAmp (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and its interaction with an abnormal ECAS's Executive score (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.045) were significant predictors of FVC. The latter indicated that patients with abnormal executive function had lower FVC than cognitively normal patients at similar PAmp values. Moreover, in patients with abnormal executive function, a reduction in PAmp was associated with a shallower decline in FVC. Severe bulbar dysfunction was also negatively associated with FVC (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>FVC may underestimate respiratory capacity in cognitively impaired patients; therefore, we recommend non\u2010volitional measures when evaluating ALS patients with executive dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70180","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:57:16Z","timestamp":1770980236000},"page":"882-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cognitive Dysfunction Is Associated With an Underestimation of Respiratory Function in\n                    <scp>ALS<\/scp>"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1807-9190","authenticated-orcid":false,"given":"Hor\u00e1cio","family":"de Jesus","sequence":"first","affiliation":[{"name":"Institute of Physiology, MUHCRI and Centro de Estudos Egas Moniz. Faculty of Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Alves","sequence":"additional","affiliation":[{"name":"Institute of Physiology, MUHCRI and Centro de Estudos Egas Moniz. Faculty of Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-8666","authenticated-orcid":false,"given":"Diana","family":"Lopes","sequence":"additional","affiliation":[{"name":"Institute of Physiology, MUHCRI and Centro de Estudos Egas Moniz. Faculty of Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sim\u00e3o","sequence":"additional","affiliation":[{"name":"Institute of Physiology, MUHCRI and Centro de Estudos Egas Moniz. Faculty of Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Catarina","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Institute of Physiology, MUHCRI and Centro de Estudos Egas Moniz. Faculty of Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2816-9698","authenticated-orcid":false,"given":"Ana Catarina","family":"Pronto\u2010Laborinho","sequence":"additional","affiliation":[{"name":"Institute of Physiology, MUHCRI and Centro de Estudos Egas Moniz. Faculty of Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Institute of Physiology, MUHCRI and Centro de Estudos Egas Moniz. Faculty of Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Oliveira Santos","sequence":"additional","affiliation":[{"name":"Institute of Physiology, MUHCRI and Centro de Estudos Egas Moniz. Faculty of Medicine University of Lisbon  Lisbon Portugal"},{"name":"Department of Neurosciences and Mental Health, ULS de Santa Maria Hospital de Santa Maria  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-0158","authenticated-orcid":false,"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Institute of Physiology, MUHCRI and Centro de Estudos Egas Moniz. Faculty of Medicine University of Lisbon  Lisbon Portugal"},{"name":"Department of Neurosciences and Mental Health, ULS de Santa Maria Hospital de Santa Maria  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(07)70265\u2010X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/912123"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14144"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2021.1905860"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.03.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.05.011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010020\u201009819\u2010y"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.04.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u2010510X(99)00210\u20105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.805784.~"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acae012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2023.2215413"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.09.015"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.5.7582303"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00143"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70180","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T13:02:45Z","timestamp":1775221365000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/mus.70180"],"URL":"https:\/\/doi.org\/10.1002\/mus.70180","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"2025-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}