{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:53:18Z","timestamp":1791568398605,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Peripheral neuropathy, especially mononeuropathy multiplex, is a frequent manifestation of leprosy. Electrodiagnostic studies (EDX) usually show predominant axonal involvement. In this study, we report patients with prominent demyelinating abnormalities consistent with the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the medical records of patients with leprosy who underwent EDX at Piti\u00e9\u2010Salp\u00eatri\u00e8re University Hospital, Paris, France, between January 2014 and June 2022. We included patients exhibiting demyelinating abnormalities that fulfilled the 2021 European Academy of Neurology\/Peripheral Nerve Society (EAN\/PNS) electrodiagnostic criteria for CIDP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten patients were included. Eight patients presented with conduction blocks (CB) and temporal dispersion (TD) outside entrapment sites, primarily localized on the median and ulnar nerves in the forearm. Eight patients demonstrated delayed or absent F\u2010waves in nerves without segmental slowing or CB\/TD. Two patients were initially diagnosed with multifocal CIDP and treated accordingly before a nerve biopsy corrected the diagnosis. Follow\u2010up EDX after anti\u2010leprosy treatment revealed partial improvement or complete resolution of CB\/TD in six patients, with improvement in distal motor amplitudes in four patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Patients with leprosy neuropathy can exhibit demyelinating abnormalities on EDX, particularly CB\/TD in the forearm, which may misleadingly suggest an immune\u2010mediated origin, such as multifocal CIDP. In patients from leprosy\u2010endemic areas with a demyelinating neuropathy fulfilling electrodiagnostic criteria for CIDP, clinicians should perform a dermatological examination, repeat bacteriological and histological sampling, and consider performing a nerve biopsy if diagnostic doubt persists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70189","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:21:32Z","timestamp":1772961692000},"page":"898-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Demyelinating Leprosy Neuropathy: An Unusual and Misleading Electrophysiological Pattern"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-0056","authenticated-orcid":false,"given":"Cendrine","family":"Foucard","sequence":"first","affiliation":[{"name":"Neurology Department, Assistance Publique\u2010H\u00f4pitaux de Paris, DMU Neurosciences H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"Department of Clinical Electrophysiology, Assistance Publique\u2010H\u00f4pitaux de Paris, DMU Neurosciences H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Jachiet","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Saint Louis APHP et Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Viala","sequence":"additional","affiliation":[{"name":"Neurology Department, Assistance Publique\u2010H\u00f4pitaux de Paris, DMU Neurosciences H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"Department of Clinical Electrophysiology, Assistance Publique\u2010H\u00f4pitaux de Paris, DMU Neurosciences H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"French National Reference Center for Rare Neuropathies Piti\u00e9 Salp\u00eatri\u00e8re  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Maisonobe","sequence":"additional","affiliation":[{"name":"Department of Clinical Electrophysiology, Assistance Publique\u2010H\u00f4pitaux de Paris, DMU Neurosciences H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re  Paris France"},{"name":"French National Reference Center for Rare Neuropathies Piti\u00e9 Salp\u00eatri\u00e8re  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0354-4367","authenticated-orcid":false,"given":"Guillaume","family":"Fargeot","sequence":"additional","affiliation":[{"name":"Neurology Department Assistance Publique\u2010H\u00f4pitaux de Paris, CHU de Bic\u00eatre  Kremlin\u2010Bic\u00eatre France"},{"name":"French National Reference Center for Rare Neuropathies  Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117288"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.12.080"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.07.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13128"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1727575"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201060"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.47276\/LR.92.3.298"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmy.ijmy_39_24"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.83.1.93"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14959"},{"key":"e_1_2_12_12_1","first-page":"255","article-title":"Classification of Leprosy According to Immunity. A Five\u2010Group System","volume":"34","author":"Ridley D. S.","year":"1966","journal-title":"International Journal of Leprosy and Other Mycobacterial Diseases"},{"key":"e_1_2_12_13_1","unstructured":"World Health Organization RO for S\u2010EA \u201cGuidelines for the Diagnosis Treatment and Prevention of Leprosy \u201d2017."},{"key":"e_1_2_12_14_1","first-page":"282","article-title":"Motor Nerve Conduction Velocity Studies of the Ulnar Nerve in Patients With Leprosy","volume":"36","author":"Hackett E. R.","year":"1968","journal-title":"International Journal of Leprosy and Other Mycobacterial Diseases"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN_553_19"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.79.3.242"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.76892"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol\u20102014\u2010001004"},{"key":"e_1_2_12_19_1","first-page":"S225","article-title":"Guidelines in Electrodiagnostic Medicine. Consensus Criteria for the Diagnosis of Partial Conduction Block","volume":"8","author":"American Association of Electrodiagnostic Medicine, Olney RK","year":"1999","journal-title":"Muscle & Nerve. Supplement"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70189","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70189","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T13:02:38Z","timestamp":1775221358000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/mus.70189"],"URL":"https:\/\/doi.org\/10.1002\/mus.70189","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}