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LOMG represents the most prevalent MG subgroup. Clinically, LOMG is characterized by a slight male predominance that becomes more pronounced with advancing age, a frequent oculo\u2010bulbar presentation at onset, and a higher incidence of potentially life\u2010threatening events at disease onset. Nonetheless, it is generally associated with a favorable prognosis, including a relatively high rate of spontaneous remission in VLOMG. The shifting epidemiological landscape of MG, marked by a notable increase in LOMG diagnoses, raises critical questions regarding the adequacy of current therapeutic approaches and whether a distinct therapeutic approach is warranted. Crucial gaps in evidence requiring further investigation include the clinical efficacy of thymectomy, as well as the optimal selection, dosing, and management of immunosuppressive agents and emerging targeted therapies in older patients.<\/jats:p>","DOI":"10.1002\/mus.70193","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:40:06Z","timestamp":1782970806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Late\u2010Onset Myasthenia Gravis: An Increasingly Frequent Clinical Entity With Distinctive Challenges"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7474-3681","authenticated-orcid":false,"given":"E.","family":"Latini","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Neurology Unit University of Pisa  Pisa Italy"},{"name":"Department of Experimental and Clinical Medicine, Division of Geriatric and Intensive Care Medicine, Careggi Hospital University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guida","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Neurology Unit University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cepele","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Neurology Unit University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maestri Tassoni","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Neurology Unit University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(15)00145\u20103"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5899.131"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/103.3.579"},{"issue":"2","key":"e_1_2_13_5_1","first-page":"257","article-title":"Acetylcholine Receptor Antibody Characteristics in Myasthenia Gravis. 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