{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:53:37Z","timestamp":1777953217575,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371411"],"award-info":[{"award-number":["82371411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2020CFB744"],"award-info":[{"award-number":["2020CFB744"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Current therapeutic management of juvenile myasthenia gravis (JMG) predominantly relies on conventional immunosuppressive therapies and expert consensus extrapolated from adult data, creating a critical gap in high\u2010quality, pediatric\u2010specific clinical evidence. The aim of this study was to assess the efficacy and safety of efgartigimod in the pediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study enrolled JMG patients (under 18\u2009years), from 12 Chinese centers, who received at least one dose of efgartigimod. Efgartigimod was administered as weekly intravenous infusions. Study visits included W0 (baseline: pretreatment) and W1\u2013W4 (weekly posttreatment follow\u2010ups). Efficacy was assessed via MG\u2010related Activities of Daily Living (MG\u2010ADL) score, Quantitative Myasthenia Gravis (QMG) score, and the MG Composite (MGC) scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventeen JMG patients (3 males, 14 females) with a median disease duration of 23\u2009months were included. At W0, 88.2% of patients were classified as Myasthenia Gravis Foundation of America (MGFA) class II\u2013V and were anti\u2010acetylcholine receptor (anti\u2010AchR) antibody positive. After efgartigimod treatment, clinically meaningful improvement (CMI) was observed in 70.6% (W1), 73% (W2), and 91.7% (W4); 66.7% achieved minimal symptom expression by W4. MG\u2010ADL and QMG scores decreased by 30% and 30.1% (W1) and by 87.6% and 71.8% (W4) compared to W0. No treatment\u2010related adverse events occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our study suggests efgartigimod is an effective therapeutic option for JMG, with favorable efficacy and safety profiles. Further studies are necessary to validate the efficacy and safety of efgartigimod in the pediatric population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70202","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:36:38Z","timestamp":1773009398000},"page":"1025-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experience Using Efgartigimod to Treat Juvenile Myasthenia Gravis in China: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"73","author":[{"given":"Jing","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyan","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Neurology Shijiazhuang City People's Hospital  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-7568","authenticated-orcid":false,"given":"Susan","family":"Luo","sequence":"additional","affiliation":[{"name":"Huashan Rare Disease Center and Department of Neurology Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bitao","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Neurology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhilan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Guiyang Medical University  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Daping Hospital, Army Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Hospital of Guizhou Medical University  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-022X","authenticated-orcid":false,"given":"Haoyou","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Guangdong Hospital of Traditional Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingjie","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-8632","authenticated-orcid":false,"given":"Zhijun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7638-2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00743"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-012-1157-z"},{"key":"e_1_2_12_5_1","first-page":"3","article-title":"Long\u2010Term Impact of Corticosteroid Therapy on Adult Height in Juvenile Myasthenia Gravis Patients: A Retrospective Multicenter Cohort Study","volume":"4","author":"Tan Y.","year":"2025","journal-title":"Rare Disease and Orphan 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https:\/\/clinicaltrials.gov\/search?cond=Myasthenia%20Gravis&intr=Eculizumab."},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-024-00649-3"},{"key":"e_1_2_12_21_1","unstructured":"\u201cA Study of Efgartigimod PH20 SC in Children Between 2 and Less Than 18\u2009Years of Age With Generalized Myasthenia Gravis \u201daccessed February 2024 https:\/\/clinicaltrials.gov\/study\/NCT06392386."},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30369-1"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51376"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.28184"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16306"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11061597"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-024-07460-5"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70202","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:35:29Z","timestamp":1777905329000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,7]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/mus.70202"],"URL":"https:\/\/doi.org\/10.1002\/mus.70202","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,7]]},"assertion":[{"value":"2025-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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