{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:53:39Z","timestamp":1777953219122,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction\/Aims<\/jats:title>\n Far field potentials (FFP) have been proposed as a reliable neurophysiological prognostic biomarker in amyotrophic lateral sclerosis (ALS). This study evaluated the utility of ulnar nerve FFP as a robust research biomarker of lower motor neuron degeneration in spinal muscular atrophy (SMA).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Peripheral neurophysiological assessments were performed in 13 participants with SMA, 19 with amyotrophic lateral sclerosis (ALS), and 19 healthy controls. The ulnar nerve was stimulated at the wrist, and motor responses were recorded over the abductor digiti minimi (ADM) muscle. Recorded measures included compound muscle action potential (CMAP), FFP and near\u2010field potential (NFP) amplitudes, and motor unit number index (MUNIX).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The FFP amplitude was significantly lower in SMA participants compared to healthy volunteers (\n p<\/jats:italic>\n \u2009<\u20090.001), but comparable to ALS (\n p<\/jats:italic>\n \u2009=\u20090.11). The FFP amplitude showed strong correlations with the Revised Upper Limb Module (RULM) (\n \u03c1<\/jats:italic>\n \u2009=\u20090.92), ALS Functional Rating Score\u2010Revised (\n \u03c1<\/jats:italic>\n \u2009=\u20090.85), upper limb MRC score (\n \u03c1<\/jats:italic>\n \u2009=\u20090.89), CMAP amplitude (\n \u03c1<\/jats:italic>\n \u2009=\u20090.97), NFP amplitude (\n \u03c1<\/jats:italic>\n \u2009=\u20090.88), and MUNIX values (\n \u03c1<\/jats:italic>\n \u2009=\u20090.84), all of which were highly statistically significant. Multiple linear regression indicated that FFP amplitude was an independent predictor of RULM (\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n FFP amplitude appears to be a promising neurophysiological biomarker for SMA, with potential utility for monitoring disease progression, particularly in a clinical trial setting.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mus.70231","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:05:37Z","timestamp":1775009137000},"page":"1089-1095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of Far\u2010Field Potentials as a Biomarker of Neurodegeneration in Spinal Muscular Atrophy"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-644X","authenticated-orcid":false,"given":"Aicee Dawn","family":"Calma","sequence":"first","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Pavey","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4495-6314","authenticated-orcid":false,"given":"Cl\u00e1udia Santos","family":"Silva","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital Sydney New South Wales Australia"},{"name":"Department of Neurology Unidade Local de Sa\u00fade de Almada\u2010Seixal Almada Portugal"},{"name":"Faculdade de Medicina\u2010Instituto de Medicina Molecular, Centro de Estudos Egas Moniz Universidade de Lisboa Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5805-0631","authenticated-orcid":false,"given":"Yukiko","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital Sydney New South Wales Australia"},{"name":"Department of Neurology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirul Ab","family":"Ghapar","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital Sydney New South Wales Australia"},{"name":"Neurology Division Ministry of Health Malaysia Putrajaya Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Concord Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C.","family":"Kiernan","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney New South Wales Australia"},{"name":"Scientia Professor of Neuroscience University of NSW Sydney New South Wales Australia"},{"name":"Department of Neurology South Eastern Sydney Local Health District Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle A.","family":"Farrar","sequence":"additional","affiliation":[{"name":"Department of Neurology Sydney Children's Hospital Network Sydney New South Wales Australia"},{"name":"Discipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine and Health The University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-5852","authenticated-orcid":false,"given":"Parvathi","family":"Menon","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-873X","authenticated-orcid":false,"given":"Steve","family":"Vucic","sequence":"additional","affiliation":[{"name":"Brain and Nerve Research Centre, Concord Clinical School University of Sydney, Concord Hospital Sydney New South Wales 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