{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:50:39Z","timestamp":1781934639132,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare disorder of the nervous system that detrimentally influences health\u2010related quality of life (HRQoL). Evidence regarding factors influencing HRQoL in CIDP is scarce. The present study aimed to evaluate the health status of CIDP patients using instruments that assess multiple domains of HRQoL and to identify predictors of HRQoL in a large sample of German patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>102 patients with CIDP \u2010 according to the criteria of the European Academy of Neurology\/Peripheral Nerve Society \u2010 were recruited between January 2013 and June 2014 from specialized neuroimmunology clinics. Response variables were the global and domain scores of the European Quality of Life\u20105 Dimensions 3 Level Version (EQ\u20105D) instrument and the World Health Organization quality of life instrument (WHOQOL). Regressor variables included the use of intravenous immunoglobulin, the use of systemic corticosteroids, sex, age, disease duration, depression, comorbidities, cognition, and sensory deficits. A control group was not assessed; unmatched normative data derived from published sources served as comparison data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to healthy population norms, HRQoL was lower among CIDP patients, with a mean EQ\u20105D index score of 0.68 (\n                      <jats:italic>SD<\/jats:italic>\n                      : 0.43) and mean visual analogue scale score of 53.8 (\n                      <jats:italic>SD<\/jats:italic>\n                      : 21.4). The lowest WHOQOL scores were found in the physical (\n                      <jats:italic>M<\/jats:italic>\n                      : 55.6,\n                      <jats:italic>SD<\/jats:italic>\n                      : 17.9) and global (\n                      <jats:italic>M<\/jats:italic>\n                      : 47.6,\n                      <jats:italic>SD<\/jats:italic>\n                      : 17.5) domains. Depression was identified as the most consistent correlate of HRQoL, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01 across all dimensions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>HRQoL is reduced in CIDP patients. Adjunct treatment of depression shows encouraging potential as a therapeutic approach to enhance HRQoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70232","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:36:41Z","timestamp":1776235001000},"page":"59-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of Life in Patients With Chronic Inflammatory Demyelinating Polyneuropathy"],"prefix":"10.1002","volume":"74","author":[{"given":"Tobias C.","family":"Blum","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1044-417X","authenticated-orcid":false,"given":"Hendrik","family":"van der Wurp","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mengel","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps\u2010University of Marburg  Marburg Germany"},{"name":"Division Translational Genomics of Neurodegenerative Diseases, Hertie\u2010Institute for Clinical Brain Research and Center of Neurology University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Fraune","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps\u2010University of Marburg  Marburg Germany"},{"name":"Department of Neurology Klinikum Christophsbad  G\u00f6ppingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Stettner","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Tackenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps\u2010University of Marburg  Marburg Germany"},{"name":"F.Hoffmann\u2010La Roche Ltd.  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Dodel","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine University Duisburg\u2010Essen  Essen Germany"},{"name":"Department of Neurology Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102014\u2010309697"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30144\u20109"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26315"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(20)30190\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010369.pub2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12302"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537\u20102995.2005.00581.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.11.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12269"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010017\u20108658\u2010x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.1.84"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010021\u201002838\u2010w"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010020\u201009916\u2010y"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15341"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20104598(199905)22:5<560:aid\u2010mus2>3.0.co;2\u2010q"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101331.2009.02930.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260972.07422.ea"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.5.596"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.4.943"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(75)90026\u20106"},{"key":"e_1_2_11_23_1","volume-title":"Manual for the Becke Depression Inventory\u2010II","author":"Beck A. 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