{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:53:41Z","timestamp":1777953221567,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aims<\/jats:title>\n                    <jats:p>Small\u2010fiber neuropathy (SFN) is a heterogeneous disorder with many established causes, but around half of all cases are idiopathic after extensive investigation. Recent pathologic studies in Parkinson disease have revealed deposition of \u237a\u2010synuclein in small sensory and autonomic nerve terminals in skin biopsy specimens, suggesting that \u237a\u2010synuclein deposition may cause SFN in patients with systemic synucleinopathies. Our aim was to investigate whether \u237a\u2010synuclein deposition may also underlie cases of SFN previously classified as idiopathic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We co\u2010stained skin biopsy specimens of 17 patients with SFN (8 idiopathic and 9 symptomatic) for \u237a\u2010synuclein and protein gene product 9.5 (PGP 9.5). Specimens had been previously obtained for clinical diagnostic purposes and were recut in 10\u2009\u03bcm sections on a freezing sliding microtome and mounted on slides followed by staining. Specimens were viewed under a Zeiss fluorescent microscope.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found PGP 9.5\u2010positive nerve terminals in all specimens, but none demonstrated positive staining for \u237a\u2010synuclein.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This suggests that \u237a\u2010synuclein deposition is not a common underlying cause of idiopathic SFN and may be specific to systemic synucleinopathies. As no neurodegenerative causes of idiopathic SFN have yet been identified, further research is needed to investigate novel causes of this common condition that is often associated with pain, autonomic dysfunction, and diminished quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.70235","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T06:31:51Z","timestamp":1775111511000},"page":"1160-1163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synuclein Deposition in Idiopathic Small\u2010Fiber Neuropathy: A Pilot Study"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0617-395X","authenticated-orcid":false,"given":"Matthew W.","family":"Schelke","sequence":"first","affiliation":[{"name":"Columbia University, Vagelos College of Physicians and Surgeons  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurenai","family":"Tanji","sequence":"additional","affiliation":[{"name":"Columbia University, Vagelos College of Physicians and Surgeons  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-8331","authenticated-orcid":false,"suffix":"III","given":"Thomas H.","family":"Brannagan","sequence":"additional","affiliation":[{"name":"Columbia University, Vagelos College of Physicians and Surgeons  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25082"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1284-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.091074"},{"key":"e_1_2_11_5_1","first-page":"157","article-title":"Undiagnosed Neuropathies: The Impact of Ancillary Investigations","volume":"5","author":"Thomas P.","year":"1996","journal-title":"Bailli\u00e8re's Clinical Neurology"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27070"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1171"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000316"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a9f449"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318186de48"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1876-1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab285"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25445"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003989"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.70235","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.70235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:35:51Z","timestamp":1777905351000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.70235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/mus.70235"],"URL":"https:\/\/doi.org\/10.1002\/mus.70235","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}